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    CYP21A2 cytochrome P450 family 21 subfamily A member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281741, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CYP21A2provided by VGNC
    Official Full Name
    cytochrome P450 family 21 subfamily A member 2provided by VGNC
    Primary source
    VGNC:VGNC:110237
    See related
    Ensembl:ENSBTAG00000047039
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CYP21
    Orthologs
    human mouse all
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    Genomic context

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    See CYP21A2 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27326529..27331308, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101903877 Neighboring gene activating transcription factor 6 beta Neighboring gene uncharacterized LOC132343672 Neighboring gene tenascin XB Neighboring gene complement C4 Neighboring gene superkiller complex protein 2-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of a bovine gene for P-450c21 (steroid 21-hydroxylase) defines a novel cytochrome P-450 gene family. Chung BC, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3487086, Free PMC Article
    2. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE. Pallan PS, et al. J Biol Chem, 2015 May 22. PMID 25855791, Free PMC Article
    3. Structural analysis of cloned cDNA for mRNA of microsomal cytochrome P-450(C21) which catalyzes steroid 21-hydroxylation in bovine adrenal cortex. Yoshioka H, et al. J Biol Chem, 1986 Mar 25. PMID 3005319
    4. Bovine steroid 21-hydroxylase: regulation of biosynthesis. John ME, et al. Biochemistry, 1986 May 20. PMID 2424492
    5. Partial amino acid sequences of two mitochondrial and two microsomal cytochrome P-450's from adrenal cortex. Ogishima T, et al. J Biochem, 1983 Nov. PMID 6654880

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid 17-alpha-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in progesterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    steroid 21-hydroxylase
    Names
    21-OHase
    P-450c21
    P450-C21
    cytochrome P-450c21
    cytochrome P450 21
    cytochrome P450 XXI
    cytochrome P450, family 21
    cytochrome P450, subfamily XXI (steroid 21-hydroxylase)
    cytochrome P450-C21
    NP_001013614.1
    XP_015315386.2
    XP_024839145.1
    XP_024839146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013596.1 → NP_001013614.1  steroid 21-hydroxylase

      See identical proteins and their annotated locations for NP_001013614.1

      Status: PROVISIONAL

      Source sequence(s)
      M11267
      UniProtKB/Swiss-Prot
      P00191
      UniProtKB/TrEMBL
      A0AAA9TGZ4
      Related
      ENSBTAP00000054564.2, ENSBTAT00000063123.2
      Conserved Domains (1) summary
      pfam00067
      Location:29 → 478
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27326529..27331308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015459900.3 → XP_015315386.2  steroid 21-hydroxylase isoform X1

      UniProtKB/TrEMBL
      A0AAA9TGZ4
      Conserved Domains (1) summary
      pfam00067
      Location:29 → 548
      p450; Cytochrome P450

    2. XM_024983378.2 → XP_024839146.1  steroid 21-hydroxylase isoform X3

      UniProtKB/TrEMBL
      A0AAA9TGZ4
      Conserved Domains (1) summary
      pfam00067
      Location:29 → 512
      p450; Cytochrome P450

    3. XM_024983377.2 → XP_024839145.1  steroid 21-hydroxylase isoform X2

      UniProtKB/TrEMBL
      A0AAA9TGZ4
      Conserved Domains (1) summary
      pfam00067
      Location:29 → 514
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00191.2 GenPept UniProtKB/Swiss-Prot:P00191

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