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    BGLAP bone gamma-carboxyglutamate protein [ Bos taurus (domestic cattle) ]

    Gene ID: 281646, updated on 4-Oct-2024

    Summary

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    Official Symbol
    BGLAPprovided by VGNC
    Official Full Name
    bone gamma-carboxyglutamate proteinprovided by VGNC
    Primary source
    VGNC:VGNC:26480
    See related
    BGD:BT23768
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    BGP
    Orthologs
    human mouse all
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    Genomic context

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    See BGLAP in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (14551205..14552249, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene polyamine modulated factor 1 Neighboring gene solute carrier family 25 member 44

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. X-ray crystal structure of bovine 3 Glu-osteocalcin. Malashkevich VN, et al. Biochemistry, 2013 Nov 26. PMID 24138653, Free PMC Article
    2. Serum osteocalcin in dairy cows: age-related changes and periparturient variation. Sato R, et al. Res Vet Sci, 2011 Oct. PMID 21300389
    3. The (1)H NMR structure of bovine Pb(2+)-osteocalcin and implications for lead toxicity. Dowd TL, et al. Biochim Biophys Acta, 2008 Nov. PMID 18793762, Free PMC Article
    4. Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro. Ivaska KK, et al. J Biol Chem, 2004 Apr 30. PMID 14970229
    5. Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone. Price PA, et al. Proc Natl Acad Sci U S A, 1976 Oct. PMID 1068450, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
      Title: Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells.
    2. Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography.
      Title: X-ray crystal structure of bovine 3 Glu-osteocalcin.
    3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows.
      Title: Serum osteocalcin in dairy cows: age-related changes and periparturient variation.
    4. A molecular mechanism of lead toxicity for calcium binding proteins.
      Title: The (1)H NMR structure of bovine Pb(2+)-osteocalcin and implications for lead toxicity.
    5. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation
      Title: Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hydroxyapatite binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of bone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to vitamin K IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    osteocalcin
    Names
    bone Gla protein
    gamma-carboxyglutamic acid-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174249.2 → NP_776674.1  osteocalcin preproprotein

      See identical proteins and their annotated locations for NP_776674.1

      Status: PROVISIONAL

      Source sequence(s)
      X53699
      UniProtKB/Swiss-Prot
      A7YEW1, P02820
      Conserved Domains (1) summary
      smart00069
      Location:33 → 97
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      14551205..14552249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02820.2 GenPept UniProtKB/Swiss-Prot:P02820

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.