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    TLR4 toll like receptor 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 281536, updated on 4-Oct-2024

    Summary

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    Official Symbol
    TLR4provided by VGNC
    Official Full Name
    toll like receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:52834
    See related
    BGD:BT12122; Ensembl:ENSBTAG00000006240
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TLR4 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 8 NC_037335.1 (107057826..107068837)

    Chromosome 8 - NC_037335.1Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene uncharacterized LOC112447849 Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037335.1 Chromosome 8 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity of the TLR4 Immunity Receptor in Czech Native Cattle Breeds Revealed Using the Pacific Biosciences Sequencing Platform. Novák K, et al. Anim Biotechnol, 2017 Jul 3. PMID 28489974
    2. Molecular characterization and expression profile of partial TLR4 gene in association to mastitis in crossbred cattle. Panigrahi M, et al. Anim Biotechnol, 2014. PMID 24669869
    3. Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Fu Y, et al. Vet Immunol Immunopathol, 2013 Jan 15. PMID 23218938
    4. Association of TLR4 polymorphisms with Mycobacterium avium subspecies paratuberculosis infection status in Canadian Holsteins. Sharma BS, et al. Anim Genet, 2015 Oct. PMID 26360329
    5. Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro. Bromfield JJ, et al. Endocrinology, 2011 Dec. PMID 21990308, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
      Title: RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
    2. Lipopolysaccharide (LPS) exposure causes an acute increase in TLR4 gene expression in cultured primary ruminal epithelial cells
      Title: Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells.
    3. Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
      Title: Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
    4. Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle.
      Title: Single-nucleotide polymorphisms in CLEC7A, CD209 and TLR4 gene and their association with susceptibility to paratuberculosis in Indian cattle.
    5. SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population
      Title: Genetic association of polymorphisms in bovine TLR2 and TLR4 genes with Mycobacterium avium subspecies paratuberculosis infection in Indian cattle population.
    6. This research reveals the effectiveness of LTF/EcoRI and TLR4/AluI loci as candidates for reproductive performance assessment in Holstein cattle.
      Title: Genetic Polymorphisms in LTF/EcoRI and TLR4/AluI loci as candidates for milk and reproductive performance assessment in Holstein cattle.
    7. Two single nucleotide polymorphisms had significant effects on the milk production for Chinese Holstein, and these SNP could be used for molecular marker-assisted selection of milk production.
      Title: Toll-like receptor 4 gene polymorphisms influence milk production traits in Chinese Holstein cows.
    8. PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells.
      Title: PGE(2) downregulates LPS-induced inflammatory responses via the TLR4-NF-κB signaling pathway in bovine endometrial epithelial cells.
    9. Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
      Title: Dominance effects estimation of TLR4 and CACNA2D1 genes for health and production traits using logistic regression.
    10. a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
      Title: Variation in the Toll-like Receptor 4 (TLR4) gene affects milk traits in dairy cows.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopolysaccharide immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 4
    Names
    toll-like receptor 4 immunity-related protein
    NP_776623.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174198.6 → NP_776623.5  toll-like receptor 4 precursor

      See identical proteins and their annotated locations for NP_776623.5

      Status: PROVISIONAL

      Source sequence(s)
      DQ839566
      UniProtKB/Swiss-Prot
      Q0MW16, Q6GV19, Q9GL65
      Related
      ENSBTAP00000008190.2, ENSBTAT00000008190.3
      Conserved Domains (4) summary
      smart00255
      Location:675 → 816
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:27 → 192
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:375 → 400
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:399 → 558
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037335.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      107057826..107068837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GL65.2 GenPept UniProtKB/Swiss-Prot:Q9GL65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials