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    NT5E 5'-nucleotidase ecto [ Bos taurus (domestic cattle) ]

    Gene ID: 281363, updated on 4-Oct-2024

    Summary

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    Gene symbol
    NT5E
    Gene description
    5'-nucleotidase ecto
    See related
    BGD:BT11043; Ensembl:ENSBTAG00000048655
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NT5E in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (63953756..64026731, complement)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin binding cytoplasmic RNA interacting protein Neighboring gene sorting nexin 14 Neighboring gene heat shock protein HSP 90-beta-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef. Komatsu T, et al. Meat Sci, 2019 Dec. PMID 31401370
    2. The ecto-5'-nucleotidase subunits in dimers are not linked by disulfide bridges but by non-covalent bonds. Martínez-Martínez A, et al. Biochim Biophys Acta, 2000 May 23. PMID 10825541
    3. Purification and cDNA cloning of bovine liver 5'-nucleotidase, a GPI-anchored protein, and its expression in COS cells. Suzuki K, et al. J Biochem, 1993 May. PMID 8340354
    4. Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus. da Silva AS, et al. Comp Immunol Microbiol Infect Dis, 2017 Apr. PMID 28504100
    5. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The degradation rate of Inosine 5'-monophosphate (IMP) in Japanese Black beef was significantly different among NT5E genotypes in the middle stage of postmortem, indicating a significant difference in the concentrations of IMP and its degradation products among NT5E genotypes
      Title: The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.
    2. study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
      Title: Ectonucleotidase and adenosine deaminase as inflammatory marker in dairy cows naturally infected by Dictyocaulus viviparus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in AMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5'-nucleotidase
    Names
    5'-NT
    5'-deoxynucleotidase
    5'-nucleotidase, ecto (CD73)
    IMP-specific 5'-nucleotidase
    ecto-5'-nucleotidase
    thymidylate 5'-phosphatase
    NP_776554.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174129.4 → NP_776554.2  5'-nucleotidase precursor

      See identical proteins and their annotated locations for NP_776554.2

      Status: PROVISIONAL

      Source sequence(s)
      BC114093
      UniProtKB/Swiss-Prot
      Q05927, Q24K05
      UniProtKB/TrEMBL
      A0A3Q1MCG3
      Related
      ENSBTAP00000071808.1, ENSBTAT00000074100.1
      Conserved Domains (3) summary
      COG0737
      Location:14 → 532
      UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
      cd07409
      Location:29 → 310
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:339 → 507
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      63953756..64026731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05927.2 GenPept UniProtKB/Swiss-Prot:Q05927

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials