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    GFAP glial fibrillary acidic protein [ Bos taurus (domestic cattle) ]

    Gene ID: 281189, updated on 12-Oct-2024

    Summary

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    Official Symbol
    GFAPprovided by VGNC
    Official Full Name
    glial fibrillary acidic proteinprovided by VGNC
    Primary source
    VGNC:VGNC:29323
    See related
    BGD:BT10734; Ensembl:ENSBTAG00000013534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GFAP in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (44611312..44620648, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene microRNA mir-2343 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187 member A Neighboring gene kinesin family member 18B Neighboring gene uncharacterized LOC104975097 Neighboring gene complement C1q like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of a heterologous monoclonal antibody for cloning and detection of glial fibrillary acidic protein in the bovine ventricular ependyma. Bouchard P, et al. Cell Tissue Res, 1999 Nov. PMID 10571109
    2. Conformation polymorphisms and targeted marker development. Kirkpatrick BW, et al. Anim Genet, 1994 Apr. PMID 8010535
    3. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. Schläfli P, et al. FEBS J, 2011 May. PMID 21418524
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139638

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of chaperone-mediated autophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glial fibrillary acidic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174065.2 → NP_776490.2  glial fibrillary acidic protein

      See identical proteins and their annotated locations for NP_776490.2

      Status: PROVISIONAL

      Source sequence(s)
      BC119892
      UniProtKB/Swiss-Prot
      Q0P5L4, Q28115, Q866S9
      UniProtKB/TrEMBL
      A0A3Q1MVU3
      Related
      ENSBTAP00000017997.4, ENSBTAT00000017997.5
      Conserved Domains (2) summary
      pfam00038
      Location:64 → 372
      Filament; Intermediate filament protein
      pfam04732
      Location:3 → 62
      Filament_head; Intermediate filament head (DNA binding) region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      44611312..44620648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010816312.4 → XP_010814614.1  glial fibrillary acidic protein isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MHT3, A0A3Q1MVU3
      Related
      ENSBTAP00000073843.2, ENSBTAT00000071297.2
      Conserved Domains (2) summary
      pfam00038
      Location:64 → 372
      Filament; Intermediate filament protein
      pfam04732
      Location:3 → 62
      Filament_head; Intermediate filament head (DNA binding) region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28115.2 GenPept UniProtKB/Swiss-Prot:Q28115

    Gene LinkOut

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