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    DRD2 dopamine receptor D2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281126, updated on 4-Oct-2024

    Summary

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    Official Symbol
    DRD2provided by VGNC
    Official Full Name
    dopamine receptor D2provided by VGNC
    Primary source
    VGNC:VGNC:54865
    See related
    BGD:BT11104; Ensembl:ENSBTAG00000010860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DRD2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (23969740..24040381, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC132342280 Neighboring gene uncharacterized LOC132342312

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bovine dopamine type-2 receptor SNP has no effect on growth, semen characteristics and prolactin concentrations in beef bulls treated with a dopamine agonist. DeCarlo AN, et al. Anim Reprod Sci, 2019 Aug. PMID 31208851
    2. A single nucleotide polymorphism in the dopamine receptor D2 gene may be informative for resistance to fescue toxicosis in angus-based cattle. Campbell BT, et al. Anim Biotechnol, 2014. PMID 24299180
    3. Effect of prolactin-release inhibition on milk production and mammary gland involution at drying-off in cows. Ollier S, et al. J Dairy Sci, 2013 Jan. PMID 23164222
    4. A second molecular form of D2 dopamine receptor in rat and bovine caudate nucleus. Chio CL, et al. Nature, 1990 Jan 18. PMID 2137198
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DRD2 genotype was not associated with semen quality, serum Prolactin, or growth traits.
      Title: Bovine dopamine type-2 receptor SNP has no effect on growth, semen characteristics and prolactin concentrations in beef bulls treated with a dopamine agonist.
    2. Studied a novel Dopamine Receptor 2 (DRD2) G/A SNP for resistance to fescue toxicosis.
      Title: A single nucleotide polymorphism in the dopamine receptor D2 gene may be informative for resistance to fescue toxicosis in angus-based cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D(2) dopamine receptor
    Names
    dopamine D2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174043.2 → NP_776468.1  D(2) dopamine receptor

      See identical proteins and their annotated locations for NP_776468.1

      Status: PROVISIONAL

      Source sequence(s)
      X51657
      UniProtKB/Swiss-Prot
      P20288
      UniProtKB/TrEMBL
      G3MWM5
      Related
      ENSBTAP00000014422.5, ENSBTAT00000014422.7
      Conserved Domains (2) summary
      pfam00001
      Location:51 → 427
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:45 → 233
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23969740..24040381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024974984.2 → XP_024830752.1  D(2) dopamine receptor isoform X1

      UniProtKB/TrEMBL
      F1N4I3, G3MWM5
      Conserved Domains (1) summary
      cd15309
      Location:35 → 437
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_005215800.5 → XP_005215857.1  D(2) dopamine receptor isoform X1

      UniProtKB/TrEMBL
      F1N4I3, G3MWM5
      Conserved Domains (1) summary
      cd15309
      Location:35 → 437
      7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20288.1 GenPept UniProtKB/Swiss-Prot:P20288

    Gene LinkOut

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