U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    AKT1 AKT serine/threonine kinase 1 [ Bos taurus (cattle) ]

    Gene ID: 280991, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AKT1provided by VGNC
    Official Full Name
    AKT serine/threonine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:25797
    See related
    Ensembl:ENSBTAG00000017636
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    AKT
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AKT1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (69229676..69250154, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1 apoptosis inducing factor Neighboring gene collagen alpha-1(I) chain Neighboring gene zinc finger and BTB domain containing 42

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. Andrade GM, et al. PLoS One, 2017. PMID 28922408, Free PMC Article
    2. The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. Oviedo-Boyso J, et al. Infect Immun, 2011 Nov. PMID 21844240, Free PMC Article
    3. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. Fitzgerald TN, et al. J Cell Physiol, 2008 Aug. PMID 18247368
    4. TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Lu J, et al. Exp Cell Res, 2006 Nov 1. PMID 16963022
    5. Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. Rovani MT, et al. Mol Reprod Dev, 2017 Jun. PMID 28337827

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of the PI3K/Akt/mTOR pathway in inflammatory regulation is independent of the activation of TLRs/NF-kappaB. Cross-talk between PI3K/Akt/mTOR and TLRs/NF-kappaB signaling pathways promote inflammation.
      Title: PI3K/Akt/mTOR signaling pathway participates in Streptococcus uberis-induced inflammation in mammary epithelial cells in concert with the classical TLRs/NF-ĸB pathway.
    2. Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum.
      Title: Prostaglandin F2α-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle.
    3. the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
      Title: The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes.
    4. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
      Title: Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
    5. Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
      Title: Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling.
    6. TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
      Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
    7. results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB.
      Title: The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells.
    8. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase, reactive oxygen species, and PI3-kinase in stimulated NO release.
      Title: 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.
    9. The intracellular mechanism of action of CART in regulation of FSH-induced MAPK signaling.
      Title: Cocaine- and amphetamine-regulated transcript accelerates termination of follicle-stimulating hormone-induced extracellularly regulated kinase 1/2 and Akt activation by regulating the expression and degradation of specific mitogen-activated protein kinase phosphatases in bovine granulosa cells.
    10. AMPK and AKT are both downstream of PI3K and that AKT activation is partially dependent on AMPK. The interrelationship between AMPK and AKT, although known to be individually important in mediating VEGF activation of eNOS, is clearly characterized.
      Title: An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    RAC-alpha serine/threonine-protein kinase
    Names
    PKB alpha
    RAC-PK-alpha
    protein kinase B alpha
    NP_776411.1
    XP_024837360.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173986.2 → NP_776411.1  RAC-alpha serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_776411.1

      Status: PROVISIONAL

      Source sequence(s)
      X61036
      UniProtKB/Swiss-Prot
      Q01314, Q5ER96
      Related
      ENSBTAP00000023461.7, ENSBTAT00000023461.7
      Conserved Domains (4) summary
      cd01241
      Location:4 → 111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124 → 479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
      pfam00069
      Location:150 → 408
      Pkinase; Protein kinase domain
      pfam00169
      Location:6 → 104
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      69229676..69250154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024981592.2 → XP_024837360.1  RAC-alpha serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q01314, Q5ER96
      Conserved Domains (2) summary
      cd01241
      Location:4 → 111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124 → 479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01314.2 GenPept UniProtKB/Swiss-Prot:Q01314

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials