PAEP progestagen-associated endometrial protein [Bos taurus (domestic cattle)] - Gene

Summary

Gene symbol: PAEP
Gene description: progestagen-associated endometrial protein
See related: BGD:BT10129; Ensembl:ENSBTAG00000014678
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: BLG; LGB
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (103255756..103260862)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conformational complexity of BLG protein-protein self-association and palmitic acid (PLM) or dodecyl sulfate (SDS) ligand recognition in the monomeric and dimeric state, was investigated.
Title: Energetic and conformational features linked to the monomeric and dimeric states of bovine BLG.
The effect of beta-lactoglobulin (beta-LG) phenotype on the fatty acid composition and antioxidant capacity of milk is variable, which could partly be the result of a beta-LG phenotype x diet interaction.
Title: Effect of supplementation of cows diet with linseed and fish oil and different variants of β-lactoglobulin on fatty acid composition and antioxidant capacity of milk.
LG plays a key role in enhancing immune responses by promoting cell proliferation through IgM receptor.
Title: β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation.
Interactions of LGB-A and LGB-B with sodium dodecyl sulfate, dodecyltrimethylammonium chloride and lauric acid, 12-carbon ligands possessing differently charged polar groups, were investigated.[LGB-A, LGB-B]
Title: The differences in binding 12-carbon aliphatic ligands by bovine β-lactoglobulin isoform A and B studied by isothermal titration calorimetry and X-ray crystallography.
Data (including data from molecular dynamic simulations) suggest that -OH groups of 3-hydroxypalmitic acid and 16-hydroxypalmitic acid act as hydrogen-bond donors in a hydrophobic protein cavity of beta-lactoglobulin. [BLG, beta-lactoglobulin]
Title: Energetics of intermolecular hydrogen bonds in a hydrophobic protein cavity.
SNPs at the exon2 region of the beta-LG gene affected milk performance traits in Chinese Holstein cattle.
Title: [The effect of genetic polymorphism of the exon 2 of the beta-lactoglobulin gene on the milk composition in Chinese Holstein].
Rate constants (k(off)) for betaLg dimer dissociation, were estimated.
Title: Bovine β-lactoglobulin is dimeric under imitative physiological conditions: dissociation equilibrium and rate constants over the pH range of 2.5-7.5.
Because of a more favorable enthalpy, the dimerization equilibrium constant of beta-LG B was larger than that of beta-LG A at room temperature, while the two dimers became similarly stable at 35 degrees C.
Title: Energetics of ligand recognition and self-association of bovine β-lactoglobulin: differences between variants A and B.
Three single nucleotide polymorphisms change beta-LG B* gene structure and expression.
Title: Polymorphism in the exon 4 of β-lactoglobulin variant B precursor gene and its association with milk traits and protein structure in Chinese Holstein.
Kinetic studies of the interaction of beta-lactoglobulin with model membranes: stopped-flow CD and fluorescence studies.
Title: Kinetic studies of the interaction of β-lactoglobulin with model membranes: stopped-flow CD and fluorescence studies.

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General gene information

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Markers

LGB (e-PCR), detects polymorphism
- UniSTS:279479

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables small molecule binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-lactoglobulin

Names: bLG C; beta lactoglobulin C; beta lactoglobulin D; beta-LG; lactoglobulin, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173929.3 → NP_776354.2 beta-lactoglobulin precursor

See identical proteins and their annotated locations for NP_776354.2

Status: PROVISIONAL

Source sequence(s)

BC108213

UniProtKB/Swiss-Prot

P02754, Q32P89

UniProtKB/TrEMBL

B5B0D4

Conserved Domains (1) summary

cd19416
Location:19 → 178

lipocalin_beta-LG-like; beta-lactoglobulin and similar proteins