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    DBH dopamine beta-hydroxylase [ Bos taurus (domestic cattle) ]

    Gene ID: 280758, updated on 4-Oct-2024

    Summary

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    Official Symbol
    DBHprovided by VGNC
    Official Full Name
    dopamine beta-hydroxylaseprovided by VGNC
    Primary source
    VGNC:VGNC:27888
    See related
    BGD:BT11121; Ensembl:ENSBTAG00000004508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See DBH in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (104498730..104516525)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene ADAMTS like 2 Neighboring gene family with sequence similarity 163 member B Neighboring gene uncharacterized LOC132346649 Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC132346651 Neighboring gene vav guanine nucleotide exchange factor 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species. Evans JP, et al. J Biol Chem, 2003 Dec 12. PMID 12966104
    2. Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase. Terland O, et al. Biochem J, 2003 Feb 1. PMID 12379149, Free PMC Article
    3. The membrane-binding segment of dopamine beta-hydroxylase is not an uncleaved signal sequence. Taylor CS, et al. J Biol Chem, 1989 Jan 5. PMID 2909511
    4. Structure of bovine adrenal dopamine beta-monooxygenase, as deduced from cDNA and protein sequencing: evidence that the membrane-bound form of the enzyme is anchored by an uncleaved signal peptide. Taljanidisz J, et al. Biochemistry, 1989 Dec 26. PMID 2620060
    5. Primary amino acid sequence of bovine dopamine beta-hydroxylase. Robertson JG, et al. J Biol Chem, 1990 Jan 15. PMID 2295597

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present study presents evidence for the conclusion that the catalytic activity of dopamine beta-hydroxylase (DBH; dopamine beta-mono-oxygenase, EC 1.14.17.1) is regulated independently by pH and by anions
      Title: Anion- and pH-dependent activation of the soluble form of dopamine beta-hydroxylase.
    2. dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase
      Title: Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dopamine beta-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in norepinephrine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in octopamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in secretory granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dopamine beta-hydroxylase
    Names
    dopamine beta-monooxygenase
    NP_851338.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180995.2 → NP_851338.1  dopamine beta-hydroxylase precursor

      See identical proteins and their annotated locations for NP_851338.1

      Status: PROVISIONAL

      Source sequence(s)
      J02890
      UniProtKB/Swiss-Prot
      P15101, Q0V8A8, Q28094, Q9TVD1
      Related
      ENSBTAP00000047899.3, ENSBTAT00000055221.3
      Conserved Domains (3) summary
      pfam01082
      Location:206 → 330
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03351
      Location:50 → 163
      DOMON; DOMON domain
      pfam03712
      Location:354 → 509
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      104498730..104516525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15101.2 GenPept UniProtKB/Swiss-Prot:P15101

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials