U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    ADM adrenomedullin [ Bos taurus (domestic cattle) ]

    Gene ID: 280713, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ADMprovided by VGNC
    Official Full Name
    adrenomedullinprovided by VGNC
    Primary source
    VGNC:VGNC:25681
    See related
    BGD:BT10911; Ensembl:ENSBTAG00000021048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADM in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (42377559..42379867, complement)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 141 Neighboring gene uncharacterized LOC101906823 Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene microRNA mir-6518 Neighboring gene SET binding factor 2 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC104974249

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Adrenomedullin regulates the speed of oviductal fluid flow in cattle. Yoshimoto Y, et al. Mol Reprod Dev, 2017 Aug. PMID 28621496
    2. Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla. Kitamura K, et al. Peptides, 2001 Nov. PMID 11754956
    3. Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine. Barker S, et al. Life Sci, 1998. PMID 9585168
    4. Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells. Takahashi K, et al. Hypertens Res, 2006 Jun. PMID 16940707
    5. Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta. Hayashi KG, et al. Reprod Biol Endocrinol, 2013 Jul 13. PMID 23849271, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studied adrenomedullin's (ADM) role in oviductal fluid flow in cattle.
      Title: Adrenomedullin regulates the speed of oviductal fluid flow in cattle.
    2. Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells.
      Title: Temporo-spatial expression of adrenomedullin and its receptors in the bovine placenta.
    3. The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells.
      Title: Expression of endothelin-1 and adrenomedullin was not altered by leptin or resistin in bovine brain microvascular endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables adrenomedullin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in adrenomedullin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    pro-adrenomedullin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173888.3 → NP_776313.1  pro-adrenomedullin precursor

      See identical proteins and their annotated locations for NP_776313.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123826
      UniProtKB/Swiss-Prot
      O62827, Q08DC5, Q95KP0
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 151
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42377559..42379867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024974972.2 → XP_024830740.1  pro-adrenomedullin isoform X2

      UniProtKB/TrEMBL
      A0AAF6Z8H7
      Related
      ENSBTAP00000028036.5, ENSBTAT00000028036.6
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 150
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. XM_005215893.5 → XP_005215950.1  pro-adrenomedullin isoform X1

      See identical proteins and their annotated locations for XP_005215950.1

      UniProtKB/Swiss-Prot
      O62827, Q08DC5, Q95KP0
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 151
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62827.2 GenPept UniProtKB/Swiss-Prot:O62827

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.