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    F2 coagulation factor II, thrombin [ Bos taurus (domestic cattle) ]

    Gene ID: 280685, updated on 17-Aug-2024

    Summary

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    Official Symbol
    F2provided by VGNC
    Official Full Name
    coagulation factor II, thrombinprovided by VGNC
    Primary source
    VGNC:VGNC:28682
    See related
    BGD:BT12387; Ensembl:ENSBTAG00000007148
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (76656848..76671235)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 1 Neighboring gene zinc finger protein 408 Neighboring gene cytoskeleton associated protein 5 Neighboring gene small nucleolar RNA SNORD67 Neighboring gene transfer RNA glutamic acid (anticodon CUC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model. Bruce AC, et al. Microcirculation, 2012 Feb. PMID 21954923, Free PMC Article
    2. The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study. Rodríguez Y, et al. Biochemistry, 2008 Dec 16. PMID 19086158
    3. Crystallization and preliminary x-ray studies of the unliganded wild-type bovine thrombin. Iyaguchi D, et al. Protein Pept Lett, 2007. PMID 18045235
    4. Structural basis for reduced staphylocoagulase-mediated bovine prothrombin activation. Friedrich R, et al. J Biol Chem, 2006 Jan 13. PMID 16230338, Free PMC Article
    5. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug. Fuentes-Prior P, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342325, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
      Title: Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation.
    2. Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics.
      Title: Functional Characterization of Antithrombin Mutations by Monitoring of Thrombin Inhibition Kinetics.
    3. the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
      Title: Kinetic regulation of the binding of prothrombin to phospholipid membranes.
    4. novel pyranosic sulfated arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated polysaccharides and glycosaminoglycans
      Title: Anticoagulant activity of a unique sulfated pyranosic (1->3)-β-L-arabinan through direct interaction with thrombin.
    5. Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
      Title: Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model.
    6. the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages
      Title: Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
    7. High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
      Title: High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells.
    8. Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1) and thereby increasing the sensitivity of the myofilament to Ca(2+).
      Title: Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries.
    9. ERK-dependent IKKalpha/beta/NF-kappaB signaling pathway plays an important role in thrombin-induced COX-2 expression in human lung fibroblasts.
      Title: Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts.
    10. These studies illustrate that GpIbalpha and gamma' target thrombin binding sites with similar consequences on thrombin dynamics, albeit with differing structural features.
      Title: Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prothrombin
    Names
    thrombin
    NP_776302.1
    XP_005216458.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173877.1 → NP_776302.1  prothrombin precursor

      See identical proteins and their annotated locations for NP_776302.1

      Status: PROVISIONAL

      Source sequence(s)
      J00041
      UniProtKB/Swiss-Prot
      P00735, Q3MHK7
      Conserved Domains (6) summary
      smart00020
      Location:366 → 616
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:25 → 89
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:212 → 294
      KR; Kringle domain
      cd00108
      Location:106 → 187
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:367 → 619
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09396
      Location:319 → 366
      Thrombin_light; Thrombin light chain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      76656848..76671235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216401.5 → XP_005216458.2  prothrombin isoform X1

      UniProtKB/Swiss-Prot
      P00735, Q3MHK7
      UniProtKB/TrEMBL
      A0A452DI66
      Related
      ENSBTAP00000009406.6, ENSBTAT00000009406.6
      Conserved Domains (5) summary
      smart00069
      Location:25 → 89
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00130
      Location:212 → 294
      KR; Kringle domain
      cd00108
      Location:106 → 187
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:367 → 625
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam09396
      Location:320 → 366
      Thrombin_light; Thrombin light chain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00735.2 GenPept UniProtKB/Swiss-Prot:P00735

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials