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    Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [ Mus musculus (house mouse) ]

    Gene ID: 27400, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hsd17b6provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 6provided by MGI
    Primary source
    MGI:MGI:1351670
    See related
    Ensembl:ENSMUSG00000025396 AllianceGenome:MGI:1351670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdh8; Hsd17b9; 17betaHSD9
    Summary
    Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process and retinol metabolic process. Predicted to be located in early endosome membrane and endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 99.6), duodenum adult (RPKM 16.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hsd17b6 in Genome Data Viewer
    Location:
    10 D3; 10 76.39 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127826800..127843517, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127990931..128007648, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28251 Neighboring gene predicted gene, 23996 Neighboring gene STARR-seq mESC enhancer starr_28252 Neighboring gene ring finger protein 181 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8376 Neighboring gene STARR-positive B cell enhancer ABC_E9812 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene Neighboring gene DNA primase, p49 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase. Su J, et al. Endocrinology, 1999 Nov. PMID 10537158
    2. HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation. Wei F, et al. Metabolism, 2023 Aug. PMID 37330135
    3. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Yi J, et al. Hepatology, 2016 Nov. PMID 27531557, Free PMC Article
    4. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article
    5. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
      Title: HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 17-beta-dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in brexanolone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brexanolone catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    17-beta-hydroxysteroid dehydrogenase type 6
    Names
    17-beta-HSD 6
    17-beta-HSD6
    17-beta-HSD9
    3-alpha->beta-HSE
    3-alpha->beta-hydroxysteroid epimerase
    hydroxysteroid (17-beta) dehydrogenase 9
    oxidative 3-alpha hydroxysteroid dehydrogenase
    NP_001346306.1
    NP_038814.1
    XP_011241766.1
    XP_011241767.1
    XP_011241769.1
    XP_011241770.1
    XP_030100965.1
    XP_030100966.1
    XP_030100967.1
    XP_030100968.1
    XP_030100969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359377.1 → NP_001346306.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120, AK008212
      Consensus CDS
      CCDS24257.1
      UniProtKB/Swiss-Prot
      Q9R092
      Related
      ENSMUSP00000151661.2, ENSMUST00000219183.2
      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001428920.1 → NP_001415849.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120
      UniProtKB/Swiss-Prot
      Q9R092

    3. NM_001428921.1 → NP_001415850.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120
      UniProtKB/Swiss-Prot
      Q9R092

    4. NM_001428922.1 → NP_001415851.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120
      UniProtKB/Swiss-Prot
      Q9R092

    5. NM_001428923.1 → NP_001415852.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC131120
      UniProtKB/Swiss-Prot
      Q9R092

    6. NM_001428924.1 → NP_001415853.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform b.
      Source sequence(s)
      AC131120

    7. NM_001428925.1 → NP_001415854.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC131120

    8. NM_013786.4 → NP_038814.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform a precursor

      See identical proteins and their annotated locations for NP_038814.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).
      Source sequence(s)
      AC131120
      Consensus CDS
      CCDS24257.1
      UniProtKB/Swiss-Prot
      Q9R092
      Related
      ENSMUSP00000151556.2, ENSMUST00000219447.2
      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_190539.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131120

    2. NR_190540.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC131120

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127826800..127843517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243465.3 → XP_011241767.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_011243464.3 → XP_011241766.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_030245105.1 → XP_030100965.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. XM_030245108.1 → XP_030100968.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_030245106.1 → XP_030100966.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. XM_030245107.1 → XP_030100967.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      UniProtKB/Swiss-Prot
      Q9R092
      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    7. XM_011243467.3 → XP_011241769.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30 → 306
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    8. XM_030245109.1 → XP_030100969.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:30 → 262
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    9. XM_011243468.3 → XP_011241770.1  17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:30 → 262
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R092.1 GenPept UniProtKB/Swiss-Prot:Q9R092

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