Rpusd2 RNA pseudouridylate synthase domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpusd2provided by MGI
Official Full Name: RNA pseudouridylate synthase domain containing 2provided by MGI
Primary source: MGI:MGI:1918066
See related: Ensembl:ENSMUSG00000027324 AllianceGenome:MGI:1918066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9630001E10; 4921503C21Rik
Summary: Predicted to enable pseudouridine synthase activity. Predicted to be involved in enzyme-directed rRNA pseudouridine synthesis and mRNA pseudouridine synthesis. Is expressed in brain; genitourinary system; parathyroid gland; and trachea. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.1), liver E14.5 (RPKM 1.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.84 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118865271..118872679)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119034790..119042198)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pseudouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables pseudouridine synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in enzyme-directed rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in mRNA pseudouridine synthesis	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pseudouridylate synthase RPUSD2

Names: RNA pseudouridylate synthase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173450.3 → NP_775626.1 pseudouridylate synthase RPUSD2

See identical proteins and their annotated locations for NP_775626.1

Status: VALIDATED

Source sequence(s)

AK044767, AL772264, BB124857

Consensus CDS

CCDS16588.1

UniProtKB/Swiss-Prot

Q149F1, Q8BXL2

Related

ENSMUSP00000028796.2, ENSMUST00000028796.2

Conserved Domains (2) summary

cd02557
Location:221 → 404

PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2

pfam08633
Location:4 → 150

Rox3; Rox3 mediator complex subunit