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    Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 270086, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ogfod1provided by MGI
    Official Full Name
    2-oxoglutarate and iron-dependent oxygenase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2442978
    See related
    Ensembl:ENSMUSG00000033009 AllianceGenome:MGI:2442978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1612; 4930415J21Rik
    Summary
    Predicted to enable peptidyl-proline 3-dioxygenase activity. Predicted to be involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 13.3), frontal lobe adult (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ogfod1 in Genome Data Viewer
    Location:
    8 C5; 8 46.08 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94763782..94794550)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94037122..94067922)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene autocrine motility factor receptor Neighboring gene nudix hydrolase 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene predicted gene, 39226

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury. Harris M, et al. Cardiovasc Res, 2022 Oct 21. PMID 34668514, Free PMC Article
    2. Deleting the ribosomal prolyl hydroxylase OGFOD1 protects mice against diet-induced obesity and insulin resistance. Rodriguez R, et al. PLoS One, 2024. PMID 38843265, Free PMC Article
    3. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility. Rodriguez R, et al. J Mol Cell Cardiol, 2023 Jun. PMID 37084634, Free PMC Article
    4. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Singleton RS, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24550447, Free PMC Article
    5. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Kim S, et al. Biol Psychiatry, 2009 Mar 1. PMID 18986647, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deleting the ribosomal prolyl hydroxylase OGFOD1 protects mice against diet-induced obesity and insulin resistance.
      Title: Deleting the ribosomal prolyl hydroxylase OGFOD1 protects mice against diet-induced obesity and insulin resistance.
    2. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
      Title: OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
    3. Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury.
      Title: Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-proline 3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-proline 3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidyl-proline dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-proline dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-proline dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-proline hydroxylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-proline hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein hydroxylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prolyl 3-hydroxylase OGFOD1
    Names
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
    uS12 prolyl 3-hydroxylase
    NP_001087226.1
    NP_808435.3
    XP_006531116.1
    XP_006531117.1
    XP_036009973.1
    XP_036009974.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093757.2 → NP_001087226.1  prolyl 3-hydroxylase OGFOD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138118
      Consensus CDS
      CCDS52636.1
      UniProtKB/TrEMBL
      D3YTU2
      Related
      ENSMUSP00000090991.3, ENSMUST00000093301.9
      Conserved Domains (1) summary
      cl21496
      Location:221 → 498
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. NM_001428379.1 → NP_001415308.1  prolyl 3-hydroxylase OGFOD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138118

    3. NM_001428381.1 → NP_001415310.1  prolyl 3-hydroxylase OGFOD1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC138118

    4. NM_001428382.1 → NP_001415311.1  prolyl 3-hydroxylase OGFOD1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC138118

    5. NM_001428383.1 → NP_001415312.1  prolyl 3-hydroxylase OGFOD1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC138118

    6. NM_001428384.1 → NP_001415313.1  prolyl 3-hydroxylase OGFOD1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC138118

    7. NM_001428385.1 → NP_001415314.1  prolyl 3-hydroxylase OGFOD1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC138118

    8. NM_001428386.1 → NP_001415315.1  prolyl 3-hydroxylase OGFOD1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC138118

    9. NM_001428387.1 → NP_001415316.1  prolyl 3-hydroxylase OGFOD1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC138118

    10. NM_001428388.1 → NP_001415317.1  prolyl 3-hydroxylase OGFOD1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC138118

    11. NM_001428389.1 → NP_001415318.1  prolyl 3-hydroxylase OGFOD1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC138118

    12. NM_001428390.1 → NP_001415319.1  prolyl 3-hydroxylase OGFOD1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC138118

    13. NM_177767.5 → NP_808435.3  prolyl 3-hydroxylase OGFOD1 isoform 1

      See identical proteins and their annotated locations for NP_808435.3

      Status: VALIDATED

      Source sequence(s)
      AC138118
      Consensus CDS
      CCDS22535.2
      UniProtKB/Swiss-Prot
      Q3TLS5, Q3TPR4, Q3U0K8, Q80TB3, Q8CFR6
      UniProtKB/TrEMBL
      D3YTU2
      Related
      ENSMUSP00000105183.3, ENSMUST00000109556.9
      Conserved Domains (2) summary
      smart00702
      Location:72 → 237
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      cl21496
      Location:262 → 541
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RNA

    1. NR_190337.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138118

    2. NR_190338.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138118

    3. NR_190340.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138118

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94763782..94794550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531054.5 → XP_006531117.1  prolyl 3-hydroxylase OGFOD1 isoform X3

      Conserved Domains (2) summary
      pfam13661
      Location:42 → 138
      2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
      cl21496
      Location:162 → 446
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_006531053.5 → XP_006531116.1  prolyl 3-hydroxylase OGFOD1 isoform X1

      Conserved Domains (2) summary
      pfam13661
      Location:84 → 180
      2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
      cl21496
      Location:204 → 488
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. XM_036154080.1 → XP_036009973.1  prolyl 3-hydroxylase OGFOD1 isoform X2

      Conserved Domains (2) summary
      pfam13661
      Location:45 → 141
      2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
      cl21496
      Location:165 → 449
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_036154081.1 → XP_036009974.1  prolyl 3-hydroxylase OGFOD1 isoform X2

      UniProtKB/TrEMBL
      D3YTU2
      Conserved Domains (2) summary
      pfam13661
      Location:45 → 141
      2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
      cl21496
      Location:165 → 449
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0K8.1 GenPept UniProtKB/Swiss-Prot:Q3U0K8

    Gene LinkOut

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