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    Cul1 cullin 1 [ Mus musculus (house mouse) ]

    Gene ID: 26965, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cul1provided by MGI
    Official Full Name
    cullin 1provided by MGI
    Primary source
    MGI:MGI:1349658
    See related
    Ensembl:ENSMUSG00000029686 AllianceGenome:MGI:1349658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cul-1
    Summary
    Predicted to enable ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including apoptotic process; cell population proliferation; and protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adrenal gland; genitourinary system; immune system; neural retina; and telencephalon. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cul1 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.9 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47430516..47503078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47453732..47526144)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_15777 Neighboring gene predicted gene, 53327 Neighboring gene STARR-seq mESC enhancer starr_15778 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:47544952-47545253 Neighboring gene STARR-seq mESC enhancer starr_15780 Neighboring gene STARR-seq mESC enhancer starr_15781 Neighboring gene STARR-positive B cell enhancer ABC_E4823 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New insights into the roles of CUL1 in mouse placenta development. Zeng L, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33933992
    2. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. Khoury J, et al. J Clin Invest, 2007 Mar. PMID 17318263, Free PMC Article
    3. Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components. Nakagawa T, et al. Adv Exp Med Biol, 2020. PMID 31898227
    4. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Wang Y, et al. Curr Biol, 1999 Oct 21. PMID 10531039
    5. Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. Li R, et al. Int J Biol Sci, 2023. PMID 37063418, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
      Title: CircCUL1 inhibits trophoblast cell migration and invasion and promotes cell autophagy by sponging hsa-miR-30e-3p in fetal growth restriction via the ANXA1/PI3K/AKT axis.
    2. New insights into the roles of CUL1 in mouse placenta development.
      Title: New insights into the roles of CUL1 in mouse placenta development.
    3. REVIEW: comprehensive overview of mouse models and discussion of the role of each CRL1 component in mouse physiology and pathology
      Title: Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components.
    4. Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
      Title: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation.
    5. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
      Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
    6. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
      Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
    7. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
      Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
    8. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
      Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
    9. Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.
      Title: Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
    10. Skp2 and Cul1 expression is repressed by GATA2, thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1) and p27(Kip1), inducing their accumulation, and suppressing hematopoietic stem cell growth
      Title: GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein monoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cullin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355550.2 → NP_001342479.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7
      UniProtKB/TrEMBL
      Q3UIA5
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_001355551.2 → NP_001342480.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7
      UniProtKB/TrEMBL
      Q3UIA5
      Related
      ENSMUSP00000122702.2, ENSMUST00000146200.8
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    3. NM_001410599.1 → NP_001397528.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7

    4. NM_001410600.1 → NP_001397529.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7

    5. NM_001410601.1 → NP_001397530.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7

    6. NM_001410602.1 → NP_001397531.1  cullin-1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7

    7. NM_012042.5 → NP_036172.1  cullin-1

      See identical proteins and their annotated locations for NP_036172.1

      Status: VALIDATED

      Source sequence(s)
      AC154014, AC154015
      Consensus CDS
      CCDS20095.1
      UniProtKB/Swiss-Prot
      Q9WTX6, Q9WUI7
      UniProtKB/TrEMBL
      Q3UIA5
      Related
      ENSMUSP00000031697.9, ENSMUST00000031697.9
      Conserved Domains (2) summary
      pfam00888
      Location:21 → 660
      Cullin; Cullin family
      pfam10557
      Location:706 → 767
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47430516..47503078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTX6.1 GenPept UniProtKB/Swiss-Prot:Q9WTX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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