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    Lhfpl3 lipoma HMGIC fusion partner-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 269629, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lhfpl3provided by MGI
    Official Full Name
    lipoma HMGIC fusion partner-like 3provided by MGI
    Primary source
    MGI:MGI:1925076
    See related
    Ensembl:ENSMUSG00000106379 AllianceGenome:MGI:1925076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930031L14Rik
    Summary
    Predicted to be involved in sensory perception of sound. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain and reproductive system. Orthologous to human LHFPL3 (LHFPL tetraspan subfamily member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.6), cerebellum adult (RPKM 7.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lhfpl3 in Genome Data Viewer
    Location:
    5 A3; 5 10.07 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22951052..23480595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (22746054..23275597)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930003O13 gene Neighboring gene predicted gene, 32711 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_12595 Neighboring gene predicted pseudogene 6564 Neighboring gene STARR-positive B cell enhancer mm9_chr5:22666753-22667054 Neighboring gene STARR-seq mESC enhancer starr_12596 Neighboring gene macrophage migration inhibitory factor, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12597 Neighboring gene STARR-seq mESC enhancer starr_12598 Neighboring gene STARR-seq mESC enhancer starr_12600 Neighboring gene SPATA31 subfamily H member 2 Neighboring gene STARR-seq mESC enhancer starr_12601 Neighboring gene STARR-seq mESC enhancer starr_12603 Neighboring gene RIKEN cDNA 5031425E22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:22892703-22893070 Neighboring gene STARR-seq mESC enhancer starr_12606 Neighboring gene STARR-seq mESC enhancer starr_12607 Neighboring gene STARR-positive B cell enhancer ABC_E1297 Neighboring gene STARR-positive B cell enhancer ABC_E528 Neighboring gene lysine (K)-specific methyltransferase 2E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells. Qiu X, et al. Cell Rep, 2023 Mar 28. PMID 36917610, Free PMC Article
    2. Novel function of LHFPL2 in female and male distal reproductive tract development. Zhao F, et al. Sci Rep, 2016 Mar 11. PMID 26964900, Free PMC Article
    3. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Longo-Guess CM, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905332, Free PMC Article
    4. Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Georgas KM, et al. Dev Dyn, 2011 Jun. PMID 21491542, Free PMC Article
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors present an overview of the Lhfp gene family in mouse and humans.
      Title: A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LHFPL tetraspan subfamily member 3 protein
    Names
    lipoma HMGIC fusion partner-like 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081231.3 → NP_001074700.2  LHFPL tetraspan subfamily member 3 protein isoform 2

      See identical proteins and their annotated locations for NP_001074700.2

      Status: VALIDATED

      Source sequence(s)
      AC123661, AC138737, AC158942
      Consensus CDS
      CCDS80218.1
      UniProtKB/Swiss-Prot
      Q9CTN8
      UniProtKB/TrEMBL
      A0A0G2JGI3
      Related
      ENSMUSP00000143576.2, ENSMUST00000197992.2
      Conserved Domains (1) summary
      pfam10242
      Location:32 → 209
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    2. NM_001359998.2 → NP_001346927.1  LHFPL tetraspan subfamily member 3 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123661, AC138737, AC158942
      Consensus CDS
      CCDS80218.1
      UniProtKB/Swiss-Prot
      Q9CTN8
      UniProtKB/TrEMBL
      A0A0G2JGI3
      Conserved Domains (1) summary
      pfam10242
      Location:32 → 209
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    3. NM_029990.2 → NP_084266.1  LHFPL tetraspan subfamily member 3 protein isoform 1

      See identical proteins and their annotated locations for NP_084266.1

      Status: VALIDATED

      Source sequence(s)
      AC123661, AC138737, AC158942
      UniProtKB/Swiss-Prot
      Q9CTN8
      Conserved Domains (1) summary
      pfam10242
      Location:32 → 209
      L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      22951052..23480595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CTN8.2 GenPept UniProtKB/Swiss-Prot:Q9CTN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials