U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Acot1 acyl-CoA thioesterase 1 [ Mus musculus (house mouse) ]

    Gene ID: 26897, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Acot1provided by MGI
    Official Full Name
    acyl-CoA thioesterase 1provided by MGI
    Primary source
    MGI:MGI:1349396
    See related
    Ensembl:ENSMUSG00000072949 AllianceGenome:MGI:1349396
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACH2; Cte1; CTE-1; CTE-I; D12Ucla1
    Summary
    Enables fatty acyl-CoA hydrolase activity. Acts upstream of or within long-chain fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 44.5), kidney adult (RPKM 41.4) and 26 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Acot1 in Genome Data Viewer
    Location:
    12 D1; 12 39.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84056276..84064444)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84009502..84017670)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_32720 Neighboring gene acyl-CoA thioesterase 2 Neighboring gene STARR-seq mESC enhancer starr_32721 Neighboring gene STARR-seq mESC enhancer starr_32722 Neighboring gene predicted gene, 40474 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure. Heden TD, et al. JCI Insight, 2023 Sep 22. PMID 37561578, Free PMC Article
    2. Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality. Xia C, et al. Biochem Biophys Res Commun, 2015 Dec 25. PMID 26518651
    3. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Yechoor VK, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149437, Free PMC Article
    4. Molecular cloning of the peroxisome proliferator-induced 46-kDa cytosolic acyl-CoA thioesterase from mouse and rat liver--recombinant expression in Escherichia coli, tissue expression, and nutritional regulation. Lindquist PJ, et al. Eur J Biochem, 1998 Feb 1. PMID 9490035
    5. Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism. Hunt MC, et al. Cell Biochem Biophys, 2000. PMID 11330065

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure.
      Title: ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure.
    2. These results suggest that ACOT1 has potential therapeutic values to protect heart from sepsis mediated dysfunction, possibly through activating PPARa/PGC1a signaling.
      Title: Cardiomyocyte specific expression of Acyl-coA thioesterase 1 attenuates sepsis induced cardiac dysfunction and mortality.
    3. ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling.
      Title: Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling.
    4. Data show that Acot1 is under regulation by an interplay between hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
      Title: The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acyl-CoA hydrolase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acyl-CoA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    acyl-coenzyme A thioesterase 1
    Names
    acyl-CoA thioesterase 1, cytosolic
    cytosolic acyl-CoA thioesterase 1
    inducible cytosolic acyl-coenzyme A thioester hydrolase
    long chain acyl-CoA hydrolase
    long chain acyl-CoA thioester hydrolase
    palmitoyl-coenzyme A thioesterase
    NP_036136.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012006.2 → NP_036136.1  acyl-coenzyme A thioesterase 1

      See identical proteins and their annotated locations for NP_036136.1

      Status: PROVISIONAL

      Source sequence(s)
      AC133183
      Consensus CDS
      CCDS36487.1
      UniProtKB/Swiss-Prot
      O55137, Q549A9
      UniProtKB/TrEMBL
      Q99L15
      Related
      ENSMUSP00000126448.2, ENSMUST00000168120.3
      Conserved Domains (3) summary
      pfam08840
      Location:204 → 410
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      pfam04775
      Location:16 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:145 → 257
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84056276..84064444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55137.1 GenPept UniProtKB/Swiss-Prot:O55137

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous