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    Has3 hyaluronan synthase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266805, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Has3provided by RGD
    Official Full Name
    hyaluronan synthase 3provided by RGD
    Primary source
    RGD:628656
    See related
    AllianceGenome:RGD:628656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hyaluronan synthase activity and identical protein binding activity. Predicted to be involved in several processes, including extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; and positive regulation of hyaluranon cable assembly. Predicted to be located in cytoplasm; hyaluranon cable; and nucleus. Predicted to be integral component of plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 38.9), Thymus (RPKM 36.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Has3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (51668276..51691042)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34768421..34782170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (39063298..39077745)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cadherin 1 Neighboring gene transport and golgi organization 6 homolog Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene UTP4 small subunit processome component Neighboring gene syntrophin, beta 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model. Mrabat H, et al. Lung, 2009 Aug. PMID 19572173
    2. EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation. Pasonen-Seppänen S, et al. J Invest Dermatol, 2003 Jun. PMID 12787132
    3. Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin. Oishi Y, et al. Biosci Biotechnol Biochem, 2003 Apr. PMID 12784612
    4. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. Karvinen S, et al. J Biol Chem, 2003 Dec 5. PMID 14506240
    5. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. Hoock TC, et al. J Cell Biol, 1997 Mar 10. PMID 9060470, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were found to be involved in the UVB-induced up-regulation of Has2 and Has3 expression.
      Title: Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
    2. Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
      Title: Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
    3. Epidermal hyaluronan synthesis, controlled by epidermal growth factor and transforming growth factor beta through changes in expression of Has2 and Has3, correlates with epidermal proliferation, thickness, and differentiation.
      Title: EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation.
    4. protein malnutrition has a primary impact on the gene expression of Has2 and Has3, which leads to the reduction of hyaluronan content and to disfunction of the skin
      Title: Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin.
    5. belongs to the targets of keratinocyte growth factor in keratinocytes, and support the idea that enhanced hyaluronan synthesis acts an effector for the migratory response of keratinocytes in wound healing
      Title: Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronan synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular polysaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hyaluranon cable assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in hyaluranon cable ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan synthase 3
    NP_758822.1
    XP_006255623.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172319.1 → NP_758822.1  hyaluronan synthase 3

      See identical proteins and their annotated locations for NP_758822.1

      Status: PROVISIONAL

      Source sequence(s)
      AB097569
      UniProtKB/TrEMBL
      A6IYX8, Q8CH92
      Conserved Domains (1) summary
      cd06434
      Location:87 → 365
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      51668276..51691042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255561.5 → XP_006255623.1  hyaluronan synthase 3 isoform X1

      See identical proteins and their annotated locations for XP_006255623.1

      UniProtKB/TrEMBL
      A6IYX8, Q8CH92
      Conserved Domains (1) summary
      cd06434
      Location:87 → 365
      GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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