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    Tbkbp1 TBK1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266764, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbkbp1provided by RGD
    Official Full Name
    TBK1 binding protein 1provided by RGD
    Primary source
    RGD:631328
    See related
    EnsemblRapid:ENSRNOG00000009370 AllianceGenome:RGD:631328
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prosapip2
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human TBKBP1 (TBK1 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 32.3), Lung (RPKM 31.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbkbp1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82616978..82632169, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82120558..82135749, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85071058..85085596, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 7 Neighboring gene T-box transcription factor 21 Neighboring gene karyopherin subunit beta 1 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene uncharacterized LOC134480862

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Liebau S, et al. Biochem Biophys Res Commun, 2009 Jul 31. PMID 19481056
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TANK-binding kinase 1-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172021.2 → NP_742018.2  TANK-binding kinase 1-binding protein 1

      See identical proteins and their annotated locations for NP_742018.2

      Status: PROVISIONAL

      Source sequence(s)
      BC076503
      UniProtKB/Swiss-Prot
      Q6DG50, Q8K1Q5
      UniProtKB/TrEMBL
      A6HIJ3
      Related
      ENSRNOP00000012461.4, ENSRNOT00000012462.6
      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 333
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:289 → 342
      TBD; TBD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82616978..82632169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085315.1 → XP_038941243.1  TANK-binding kinase 1-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q6DG50, Q8K1Q5
      UniProtKB/TrEMBL
      A6HIJ3
      Conserved Domains (2) summary
      TIGR02168
      Location:50 → 333
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:289 → 342
      TBD; TBD domain

    2. XM_063268494.1 → XP_063124564.1  TANK-binding kinase 1-binding protein 1 isoform X1

    3. XM_063268495.1 → XP_063124565.1  TANK-binding kinase 1-binding protein 1 isoform X1

    4. XM_063268496.1 → XP_063124566.1  TANK-binding kinase 1-binding protein 1 isoform X2

    5. XM_063268493.1 → XP_063124563.1  TANK-binding kinase 1-binding protein 1 isoform X1

    6. XM_039085316.2 → XP_038941244.1  TANK-binding kinase 1-binding protein 1 isoform X4

      Conserved Domains (2) summary
      TIGR02168
      Location:53 → 340
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam12845
      Location:288 → 341
      TBD; TBD domain

    7. XM_063268497.1 → XP_063124567.1  TANK-binding kinase 1-binding protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DG50.1 GenPept UniProtKB/Swiss-Prot:Q6DG50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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