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    Bles03 basophilic leukemia expressed protein BLES03 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266609, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Bles03provided by RGD
    Official Full Name
    basophilic leukemia expressed protein BLES03provided by RGD
    Primary source
    RGD:628612
    See related
    EnsemblRapid:ENSRNOG00000020551 AllianceGenome:RGD:628612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Orthologous to human C11orf68 (chromosome 11 open reading frame 68). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 70.5), Brain (RPKM 69.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212163892..212166146)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202734555..202736809)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220806563..220808817)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483957 Neighboring gene testis specific 10 interacting protein Neighboring gene Dr1 associated protein 1 Neighboring gene FOS like 1, AP-1 transcription factor subunit Neighboring gene coiled-coil domain containing 85B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03. Bitto E, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Sep 1. PMID 16511166, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural characterization of the human ortholog.
      Title: The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    UPF0696 protein C11orf68 homolog
    Names
    basophilic leukemia-expressed protein Bles03

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024233.2 → NP_001019404.2  UPF0696 protein C11orf68 homolog isoform 1

      See identical proteins and their annotated locations for NP_001019404.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF502571, BC093387, CK596744
      UniProtKB/Swiss-Prot
      A0A0H2UHS1, Q566Q8, Q8K436
      Related
      ENSRNOP00000027869.6, ENSRNOT00000027869.9
      Conserved Domains (1) summary
      pfam08939
      Location:156 → 253
      DUF1917; Domain of unknown function (DUF1917)

    2. NM_001243534.1 → NP_001230463.1  UPF0696 protein C11orf68 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212163892..212166146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q566Q8.2 GenPept UniProtKB/Swiss-Prot:Q566Q8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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