CKAP2 cytoskeleton associated protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CKAP2provided by HGNC
Official Full Name: cytoskeleton associated protein 2provided by HGNC
Primary source: HGNC:HGNC:1990
See related: Ensembl:ENSG00000136108 MIM:611569; AllianceGenome:HGNC:1990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LB1; TMAP; se20-10
Summary: This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]
Expression: Broad expression in bone marrow (RPKM 15.6), testis (RPKM 14.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (52455478..52476627)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (51670301..51692112)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (53029613..53050762)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
Title: CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma.
Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1alpha-induced transcription of CKAP2.
Title: Long non-coding RNA DLEU1 promotes malignancy of breast cancer by acting as an indispensable coactivator for HIF-1α-induced transcription of CKAP2.
LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
Title: LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis.
Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
Title: Cytoskeleton-associated protein 2 (CKAP2) is regulated by vascular endothelial growth factor and p53 in retinal capillary endothelial cells under high-glucose conditions.
CKAP2 acts as a functional oncogene in cervical carcinoma development and may exert its function by targeting FAK-ERK2 signaling pathway.
Title: Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines.
Knockdown of CKAP2 expression effectively suppressed the proliferation and induced the apoptosis by inhibiting the phosphorylation of JAK2/STAT3 of osteosarcoma cells.
Title: Silencing of cytoskeleton-associated protein 2 represses cell proliferation and induces cell cycle arrest and cell apoptosis in osteosarcoma cells.
High CKAP2 expression is associated with highgrade glioma.
Title: CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma.
High CKAP2 expression is associated with Ovarian Cancer.
Title: CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway.
Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.
Title: Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer.
The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.
Title: RHOA, SEMA3B, and CKAP2 expression in leukaemia of different types: the results of a pilot experiment.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:594944 (e-PCR)
- UniSTS:158012

RH47265 (e-PCR)
- UniSTS:78661

RH71387 (e-PCR)
- UniSTS:15712

STS-X75342 (e-PCR)
- UniSTS:8806

IGLC6 (e-PCR)
- UniSTS:266610

A008Q05 (e-PCR)
- UniSTS:30604

RH71287 (e-PCR)
- UniSTS:12709

D22S1040 (e-PCR)
- UniSTS:38058

WI-12628 (e-PCR)
- UniSTS:22478

WI-19223 (e-PCR)
- UniSTS:38867

RH106549 (e-PCR)
- UniSTS:209623

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoskeleton-associated protein 2

Names: CTCL tumor antigen se20-10; tumor- and microtubule-associated protein; tumor-associated microtubule-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098525.3 → NP_001091995.1 cytoskeleton-associated protein 2 isoform 2

See identical proteins and their annotated locations for NP_001091995.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is longer than isoform 1.

Source sequence(s)

AI499799, AY062261, EC439890, Y15758

Consensus CDS

CCDS41893.1

UniProtKB/Swiss-Prot

A2BDE0, A5YM58, B4DR35, E9PD90, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q8WWK9, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4

UniProtKB/TrEMBL

B2RMQ4

Related

ENSP00000367276.4, ENST00000378037.9

Conserved Domains (1) summary

pfam15297
Location:326 → 673

CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
NM_001286686.2 → NP_001273615.1 cytoskeleton-associated protein 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.

Source sequence(s)

AI499799, AK299083, AY062261, EC439890

Consensus CDS

CCDS66557.1

UniProtKB/TrEMBL

B2RMQ4

Related

ENSP00000417830.1, ENST00000490903.5

Conserved Domains (1) summary

pfam15297
Location:277 → 624

CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
NM_001286687.2 → NP_001273616.1 cytoskeleton-associated protein 2 isoform 4

See identical proteins and their annotated locations for NP_001273616.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as CKAP2-s) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AA308726, AY062262

Consensus CDS

CCDS73578.1

UniProtKB/Swiss-Prot

Q8WWK9

Related

ENSP00000367273.2, ENST00000378034.7

Conserved Domains (1) summary

pfam15297
Location:325 → 492

CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
NM_018204.5 → NP_060674.3 cytoskeleton-associated protein 2 isoform 1

See identical proteins and their annotated locations for NP_060674.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AI499799, AK022982, AY062261, EC439890

Consensus CDS

CCDS9435.1

UniProtKB/TrEMBL

B2RMQ4

Related

ENSP00000258607.5, ENST00000258607.10

Conserved Domains (1) summary

pfam15297
Location:325 → 672

CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

52455478..52476627

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005266344.5 → XP_005266401.1 cytoskeleton-associated protein 2 isoform X1

UniProtKB/TrEMBL

B2RMQ4

Conserved Domains (1) summary

pfam15297
Location:278 → 625

CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
XM_047430268.1 → XP_047286224.1 cytoskeleton-associated protein 2 isoform X2