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    L3 capsid protein precursor pVI;hexon;protease [ Human mastadenovirus C ]

    Gene ID: 2652998, updated on 6-Jun-2024

    Summary

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    Gene symbol
    L3
    Gene description
    capsid protein precursor pVI;hexon;protease
    Locus tag
    HAdVC_gp08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human mastadenovirus C (serotype: Human adenovirus 2, acronym: HAdV-2, acronym: HAdV-C, nat-host: Homo sapiens)
    Lineage
    Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus
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    Genomic context

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    Sequence:
    NC_001405.1 (6008..22443)

    NC_001405.1Genomic Context describing neighboring genes Neighboring gene control protein E1A;control protein E1A 243R Neighboring gene control protein E1B 19K;control protein E1B 55K Neighboring gene encapsidation protein IVa2 Neighboring gene capsid protein IX Neighboring gene DNA polymerase;terminal protein precursor pTP Neighboring gene capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K Neighboring gene fiber Neighboring gene core protein V;core protein precursor pVII;core protein precursor pX;penton base Neighboring gene capsid protein precursor pIIIa;encapsidation protein 52K;protein 13.6K Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene single-stranded DNA-binding protein Neighboring gene Neighboring gene control protein E3 12.5K;membrane glycoprotein E3 CR1-alpha;membrane glycoprotein E3 CR1-beta;membrane glycoprotein E3 gp19K Neighboring gene control protein E3 14.7K;membrane protein E3 RID-alpha;membrane protein E3 RID-beta Neighboring gene protein U

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001405.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis. Moyer CL, et al. Virology, 2012 Jun 20. PMID 22516138, Free PMC Article
    2. Functional genetic and biophysical analyses of membrane disruption by human adenovirus. Moyer CL, et al. J Virol, 2011 Mar. PMID 21209115, Free PMC Article
    3. A capsid-encoded PPxY-motif facilitates adenovirus entry. Wodrich H, et al. PLoS Pathog, 2010 Mar 19. PMID 20333243, Free PMC Article
    4. Genetic reconstitution of the human adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape. Imelli N, et al. Virol J, 2009 Oct 27. PMID 19860872, Free PMC Article
    5. The amphipathic helix of adenovirus capsid protein VI contributes to penton release and postentry sorting. Martinez R, et al. J Virol, 2015 Feb. PMID 25473051, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results reveal that conformational changes involving hexon hypervariable region 1 are the basis for a novel viral mechanism controlling capsid transport to the nucleus by dynein.
      Title: Conformational changes in the adenovirus hexon subunit responsible for regulating cytoplasmic dynein recruitment.
    2. Authors show that the amphipathic helix of protein VI contributes to capsid stability by preventing premature disassembly and deployment of pentons and protein VI.
      Title: The amphipathic helix of adenovirus capsid protein VI contributes to penton release and postentry sorting.
    3. The L1 52/55k protein is is the seventh substrate for L3.
      Title: Processing of the l1 52/55k protein by the adenovirus protease: a new substrate and new insights into virion maturation.
    4. Amino acid substitutions in the potential nuclear export signal in L4-100K resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.
      Title: Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis.
    5. Disulfide-bond formation by a single cysteine mutation in protein VI impairs capsid release and membrane lysis.
      Title: Disulfide-bond formation by a single cysteine mutation in adenovirus protein VI impairs capsid release and membrane lysis.
    6. These studies indicate that protein VI is the critical membrane lytic factor of AdV during cellular entry and reveal the biochemical basis for its membrane interactions.
      Title: Functional genetic and biophysical analyses of membrane disruption by human adenovirus.
    7. PPxY motif within protein VI recruits Nedd4 E3 ubiquitin ligases to bind and ubiquitylate protein VI in virus entry
      Title: A capsid-encoded PPxY-motif facilitates adenovirus entry.
    8. The data show that no other mutations than P137L in the viral protease are necessary to give rise to particles that are defective in capsid processing and endosomal escape.
      Title: Genetic reconstitution of the human adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape.
    9. Analysis of FX binding to Ad5 HVRs 5 & 7 identified domains & amino acids critical for this interaction. A model of the Ad5-FX interaction using crystallographic and cryo-electron microscopic data identified contact points.
      Title: Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.
    10. Study shows that Coagulation factor X (FX) binds to the Adenovirus 5 hexon, not fiber, via an interaction between the FX Gla domain and hypervariable regions of the hexon surface.
      Title: Adenovirus serotype 5 hexon mediates liver gene transfer.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    prim_transcript

    • Loc: 6039-14113 experiment = transcript mapping
    • Loc: 6039-17969 experiment = transcript mapping
    • Loc: 6039-22443 experiment = transcript mapping

    regulatory

    • Loc: 14092-14097 regulatory_class = polyA_signal_sequence
    • Loc: 17949-17954 regulatory_class = polyA_signal_sequence
    • Loc: 22418-22423 regulatory_class = polyA_signal_sequence
    • Loc: 6008-6013 regulatory_class = TATA_box

    General protein information

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    Preferred Names
    capsid protein precursor pVI;hexon;protease
    NP_040524.1
    • genus-common

    VOG classification

    Description:

    • VOGd0015 [S] Hexon-associated protein VI
    • Structural Proteins
    NP_040525.1
    • genus-common

    VOG classification

    Description:

    • VOGd0016 [S] Hexon protein
    • Structural Proteins
    NP_040526.1
    • genus-common

    VOG classification

    Description:

    • VOGd0017 [A] Virus core assembly adenovirus-like proteinase
    • Auxilary Proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001405.1 Reference assembly

      Range
      6008..22443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040524.1 capsid protein precursor pVI [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040524.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03274
      UniProtKB/TrEMBL
      A0A3Q9HJV2, A0A3Q9HK01, A0A4P2SHD5, A0A5J6SFS0, A0A6M6A9G9, A0AAF1BTC7, A8D0M3, J9Z378
      Conserved Domains (1) summary
      pfam02993
      Location:6 → 250
      MCPVI; Minor capsid protein VI

    2. NP_040525.1 hexon [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040525.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03277
      UniProtKB/TrEMBL
      A0A3Q9HKJ5, A0A3Q9HL22, A0A3S9SNW1, A0A4P2SH31, A0A6M2Y9L7, A0A6M2Y9M8, A0A6M2Y9P7, A0A6M2Y9R4, A0A6M2Y9R8, A0A6M2Y9S9, A0A6M2Y9U1, A0A6M2Y9U4, A0A6M2Y9U7, A0A6M2Y9U9, A0A6M2Y9V6, A0A6M2Y9V9, A0A6M2Y9W0, A0A6M2Y9W1, A0A6M2Y9W2, A0A6M2Y9X1, A0A6M2Y9X3, A0A6M2Y9X9, A0A6M2Y9Y0, A0A6M2Y9Y2, A0A6M2YA08, A0A6M2YA13, A0A6M2YA14, A0A6M2YA23, A0A6M2YA24, A0A6M2YA36, A0A6M2YA39, A0A6M2YA40, A0A6M2YA46, A0A6M2YA71, A0A6M2YA87, A0A6M2YA89, A0A6M2YAA1, A0A6M2YAC2, A0A6M2YAD1, A0A6M2YAE8, A0A6M2YAG5, A0A6M2YAH4, A0A6M2YAK3, A0A6M2YAL3, A0A6M2YAR5, A0A6M2YAR7, A0A6M2YAU5, A0A6M2YAU7, A0A6M2YAW5, A0A6M2YAX0, A0A6M2YAX5, A0A6M2YAY3, A0A6M2YAY8, A0A6M2YAZ6, A0A6M2YB23, A0A6M2YB25, A0A6M2YB43, A0A6M2YB47, A0A6M2YB48, A0A6M2YB51, A0A6M2YB57, A0A6M2YB64, A0A6M2YB65, A0A6M2YB69, A0A6M2YB75, A0A6M2YB76, A0A6M2YB82, A0A6M2YB98, A0A6M2YBB9, A0A6M2YBF3, A0A6M2YBJ6, A0A6M2YBK3, A0A6M2YBL6, A0A6M6A9V6, A0AAF1BTZ6, J9Z2Q0, Q564J3, Q7TEI0, Q910Z8, Q912J7
      Conserved Domains (2) summary
      pfam03678
      Location:652 → 874
      Adeno_hexon_C; Hexon, adenovirus major coat protein, C-terminal domain
      pfam01065
      Location:8 → 651
      Adeno_hexon; Hexon, adenovirus major coat protein, N-terminal domain

    3. NP_040526.1 protease [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040526.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03252
      UniProtKB/TrEMBL
      A0A0U5BYT4, A0A1U9ALK9, A0A3Q9HLE3, A0A3S9SPU7, A0A3S9SR86, A0A4P2SGX8, A0A5J6SFC7, A0AAF0YXB7, A8D0M8, E1U5P1, J7IDL4, J9Z4X3, J9Z5L6, Q71BW7, T1UGA0
      Conserved Domains (1) summary
      pfam00770
      Location:21 → 200
      Peptidase_C5; Adenovirus endoprotease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAA92214.1
    AAA92215.1
    AAA92216.1

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