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    Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 26412, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Map4k2provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 2provided by MGI
    Primary source
    MGI:MGI:1346883
    See related
    Ensembl:ENSMUSG00000024948 AllianceGenome:MGI:1346883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCK; BL44; Rab8ip
    Summary
    Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi membrane and basolateral plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map4k2 in Genome Data Viewer
    Location:
    19 A; 19 4.46 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6391023..6405649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6340990..6355619)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene CDC42 binding protein kinase gamma Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene multiple endocrine neoplasia 1 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene STARR-positive B cell enhancer ABC_E1209 Neighboring gene predicted gene, 57665 Neighboring gene splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Ren M, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643544, Free PMC Article
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143893, MGC143894

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 2
    Names
    MAPK/ERK kinase kinase kinase 2
    MEK kinase kinase 2
    MEKKK 2
    RAB8 interacting protein
    germinal center kinase
    rab8-interacting protein
    NP_001278716.1
    NP_001402757.1
    NP_033032.1
    XP_006531818.1
    XP_006531819.1
    XP_006531820.1
    XP_006531823.1
    XP_017173700.1
    XP_017173701.1
    XP_036017493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291787.2 → NP_001278716.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_001278716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC127556
      UniProtKB/TrEMBL
      Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:400 → 712
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 183
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001415828.1 → NP_001402757.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127556

    3. NM_009006.4 → NP_033032.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_033032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC127556
      Consensus CDS
      CCDS29503.1
      UniProtKB/Swiss-Prot
      Q61161
      UniProtKB/TrEMBL
      Q3U4B8
      Related
      ENSMUSP00000025897.7, ENSMUST00000025897.13
      Conserved Domains (3) summary
      smart00036
      Location:489 → 801
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:16 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16 → 272
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RNA

    1. NR_117093.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) retains an intron and uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC127556, AK011708, AK051036, BC034109, BY753233

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6391023..6405649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531755.4 → XP_006531818.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006531818.1

      UniProtKB/TrEMBL
      Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:434 → 746
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:50 → 217
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036161600.1 → XP_036017493.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X3

      UniProtKB/TrEMBL
      Q3U4B8
      Related
      ENSMUST00000133696.8
      Conserved Domains (2) summary
      smart00036
      Location:423 → 735
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:39 → 206
      PKc_like; Protein Kinases, catalytic domain

    3. XM_017318211.3 → XP_017173700.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      Q14B83, Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:445 → 757
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:38 → 228
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006531760.5 → XP_006531823.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X4

      See identical proteins and their annotated locations for XP_006531823.1

      UniProtKB/TrEMBL
      Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:400 → 712
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 183
      PKc_like; Protein Kinases, catalytic domain

    5. XM_017318212.2 → XP_017173701.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

      UniProtKB/TrEMBL
      Q14B83, Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:445 → 757
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:38 → 228
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006531756.4 → XP_006531819.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006531819.1

      UniProtKB/TrEMBL
      Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:434 → 746
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:50 → 217
      PKc_like; Protein Kinases, catalytic domain

    7. XM_006531757.2 → XP_006531820.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

      See identical proteins and their annotated locations for XP_006531820.1

      UniProtKB/TrEMBL
      Q3U4B8
      Conserved Domains (2) summary
      smart00036
      Location:434 → 746
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:50 → 217
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001782591.3 RNA Sequence

      Related
      ENSMUST00000124556.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61161.1 GenPept UniProtKB/Swiss-Prot:Q61161

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