Map3k1 mitogen-activated protein kinase kinase kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map3k1provided by MGI
Official Full Name: mitogen-activated protein kinase kinase kinase 1provided by MGI
Primary source: MGI:MGI:1346872
See related: Ensembl:ENSMUSG00000021754 AllianceGenome:MGI:1346872
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mekk; MEKK1; MAPKKK1
Summary: Enables JUN kinase kinase kinase activity; MAP kinase kinase activity; and cytoskeletal protein binding activity. Involved in positive regulation of JUN kinase activity. Acts upstream of or within several processes, including eyelid development in camera-type eye; positive regulation of actin filament polymerization; and transforming growth factor beta receptor signaling pathway. Part of filamentous actin. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 7.6), thymus adult (RPKM 6.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.36 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (111882962..111954803, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (111746428..111818269, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia.
Title: MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia.
MAP3K1 regulates female reproductive tract development.
Title: MAP3K1 regulates female reproductive tract development.
The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.
Title: The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells.
Genetic Control of MAP3K1 in Eye Development and Sex Differentiation.
Title: Genetic Control of MAP3K1 in Eye Development and Sex Differentiation.
An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.
Title: An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.
Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1.
Title: Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1.
Data identify a unique signal crosstalk between Wnt signaling and the MAP3K1-JNK pathway in epithelial morphogenesis.
Title: Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.
These results reveal the importance of the MEKK1-calponin-3 signaling pathway to cell contractility.
Title: MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility.
Map3k1 regulates iNKT cell proliferative expansion in response to glycolipid antigen
Title: T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion.
goya and kinase-deficient Map3k1 homozygotes initially develop supernumerary cochlear outer hair cells (OHCs) that subsequently degenerate.
Title: The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (4)
Gene trapped (1)
Spontaneous (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN28005 (e-PCR)
- UniSTS:352805

RH74713 (e-PCR)
- UniSTS:116522

G67066 (e-PCR)
- UniSTS:178275

Map3k1 (e-PCR), detects polymorphism
- UniSTS:143820

Map3k1 (e-PCR), detects polymorphism
- UniSTS:143821

Map3k1 (e-PCR), detects polymorphism
- UniSTS:143822

ECD10515 (e-PCR)
- UniSTS:291554

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase activity	EXP Inferred from Experiment more info	PubMed
enables MAP kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sphingolipid binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic mitochondrial changes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eyelid development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelial sheet	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
part_of filamentous actin	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 1

Names: MAPK/ERK kinase kinase 1; MEK kinase 1

NP_036075.2

EC 2.7.11.25

XP_017171005.1

EC 2.7.11.25

XP_036013944.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011945.3 → NP_036075.2 mitogen-activated protein kinase kinase kinase 1

See identical proteins and their annotated locations for NP_036075.2

Status: VALIDATED

Source sequence(s)

AC118704

Consensus CDS

CCDS26771.1

UniProtKB/Swiss-Prot

P53349, Q60831, Q9R0U3, Q9R256

UniProtKB/TrEMBL

F8VQ72

Related

ENSMUSP00000104890.3, ENSMUST00000109267.9

Conserved Domains (2) summary

smart00220
Location:1224 → 1489

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06630
Location:1223 → 1490

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

111882962..111954803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315516.2 → XP_017171005.1 mitogen-activated protein kinase kinase kinase 1 isoform X2

UniProtKB/Swiss-Prot

P53349, Q60831, Q9R0U3, Q9R256

Conserved Domains (2) summary

cd06630
Location:1075 → 1342

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:287 → 342

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
XM_036158051.1 → XP_036013944.1 mitogen-activated protein kinase kinase kinase 1 isoform X1

UniProtKB/Swiss-Prot

P53349, Q60831, Q9R0U3, Q9R256

Conserved Domains (2) summary

cd06630
Location:1143 → 1410

STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1

cd16494
Location:355 → 410

RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins