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    Pcsk6 proprotein convertase subtilisin/kexin type 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25507, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pcsk6provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 6provided by RGD
    Primary source
    RGD:3246
    See related
    EnsemblRapid:ENSRNOG00000011526 AllianceGenome:RGD:3246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spc4; Pace4
    Summary
    Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Involved in peptide hormone processing. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 199.7), Liver (RPKM 95.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcsk6 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (128839742..129038087)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119428978..119627626)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (126749508..126947392)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547214 Neighboring gene uncharacterized LOC102549305 Neighboring gene ribosomal protein S29, pseudogene 9 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene selenoprotein S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of pro-protein convertase subtilisin/kexin type 6 has a protective role against synovitis in a rat model of rheumatoid arthritis. Jiang H, et al. Mol Med Rep, 2015 Nov. PMID 26458419
    2. Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland. Akamatsu T, et al. Dev Dyn, 2007 Jan. PMID 17083113
    3. Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland. Akamatsu T, et al. Dev Biol, 2009 Jan 15. PMID 19013448
    4. Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix. Tsuji A, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535616
    5. Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). Nagahama M, et al. FEBS Lett, 1998 Aug 28. PMID 9738469

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCSK6 knockdown significantly decreased the cell proliferation, invasion and migration of fibroblastlike synoviocytes from rats with collageninduced arthritis.
      Title: Inhibition of pro-protein convertase subtilisin/kexin type 6 has a protective role against synovitis in a rat model of rheumatoid arthritis.
    2. PACE4 regulates the SMG development via the activation of some growth/differentiation factors.
      Title: Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland.
    3. temporospatially regulated expression of PACE4 suggests its apparent association with the proliferation, differentiation, and establishment of functional acinar and ductal cells of the submandibular gland.
      Title: Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland.
    4. Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.
      Title: A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nerve growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nerve growth factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nerve growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide hormone processing IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in secretion by cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in secretion by cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in zygotic determination of anterior/posterior axis, embryo IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 6
    Names
    Subtilisin - like endoprotease
    kexin-like protease PC7A
    paired basic amino acid cleaving enzyme 4
    subtilisin-like proprotein convertase 4
    subtilisin/kexin-like protease PACE4
    NP_037131.2
    XP_038957724.1
    XP_038957726.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012999.2 → NP_037131.2  proprotein convertase subtilisin/kexin type 6 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q63415
      UniProtKB/TrEMBL
      F1LNB4
      Related
      ENSRNOP00000015845.9, ENSRNOT00000015845.9
      Conserved Domains (7) summary
      cd04059
      Location:141 → 435
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:812 → 854
      FU; Furin-like repeats
      cd00064
      Location:768 → 813
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:520 → 610
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:910 → 933
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:662 → 772
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:56 → 132
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      128839742..129038087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101796.2 → XP_038957724.1  proprotein convertase subtilisin/kexin type 6 isoform X1

      UniProtKB/Swiss-Prot
      Q63415
      UniProtKB/TrEMBL
      A0A8I5ZLS8
      Related
      ENSRNOP00000078906.2, ENSRNOT00000106454.2
      Conserved Domains (7) summary
      cd04059
      Location:141 → 435
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:825 → 867
      FU; Furin-like repeats
      cd00064
      Location:781 → 826
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:520 → 610
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:923 → 946
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:675 → 785
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:56 → 132
      S8_pro-domain; Peptidase S8 pro-domain

    2. XM_039101798.2 → XP_038957726.1  proprotein convertase subtilisin/kexin type 6 isoform X2

      UniProtKB/TrEMBL
      A6JBN6
      Conserved Domains (6) summary
      cd04059
      Location:2 → 215
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:605 → 647
      FU; Furin-like repeats
      cd00064
      Location:561 → 606
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:300 → 390
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:703 → 726
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:455 → 565
      GF_recep_IV; Growth factor receptor domain IV
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63415.1 GenPept UniProtKB/Swiss-Prot:Q63415

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