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    cnx1 calnexin Cnx1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cnx1
    Official Full Name
    calnexin Cnx1
    Primary source
    PomBase:SPAC3C7.11c
    Locus tag
    SPOM_SPAC3C7.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cal1
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    Genomic context

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    See cnx1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2086393..2088324, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AAA family ATPase Elf1 Neighboring gene ncRNA Neighboring gene lysine methyltransferase Set8 Neighboring gene peroxin 13 Neighboring gene ncRNA Neighboring gene glucose-6-phosphate 1-dehydrogenase Neighboring gene CLIP170 family protein Tip1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast. Guérin R, et al. Mol Biol Cell, 2008 Oct. PMID 18701708, Free PMC Article
    2. The calnexin homologue cnx1+ in Schizosaccharomyces pombe, is an essential gene which can be complemented by its soluble ER domain. Parlati F, et al. EMBO J, 1995 Jul 3. PMID 7621821, Free PMC Article
    3. The Schizosaccharomyces pombe homologue of the chaperone calnexin is essential for viability. Jannatipour M, et al. J Biol Chem, 1995 Mar 3. PMID 7876257
    4. A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin. Beauregard PB, et al. J Cell Sci, 2009 May 1. PMID 19351719
    5. The 160 N-terminal residues of calnexin define a novel region supporting viability in Schizosaccharomyces pombe. Hajjar F, et al. Yeast, 2007 Feb. PMID 17230581

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cnx1p is required for cell survival under nitrogen-starvation and in chronological aging cultures.
      Title: Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.
    2. Nucleolar localization of Cif1p is required to induce the calnexin-independent state, suggesting an unexpected interaction between the cellular role of calnexin and a function of the nucleolus.
      Title: A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin.
    3. Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast
      Title: Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calnexin Cnx1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2086393..2088324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356049.2 → NP_001342872.1  calnexin Cnx1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36581
      Conserved Domains (1) summary
      pfam00262
      Location:42 → 406
      Calreticulin; Calreticulin family
    Nucleotide Protein
    Heading Accession and Version

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