U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    fep1 Fe-sensing transcription factor Fep1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541522, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fep1
    Official Full Name
    Fe-sensing transcription factor Fep1
    Primary source
    PomBase:SPAC23E2.01
    Locus tag
    SPOM_SPAC23E2.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    gaf2
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fep1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (442221..445721)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The iron uptake repressor Fep1 in the fission yeast binds Fe-S cluster through conserved cysteines. Kim HJ, et al. Biochem Biophys Res Commun, 2016 Sep 9. PMID 27444384
    2. Iron activates in vivo DNA binding of Schizosaccharomyces pombe transcription factor Fep1 through its amino-terminal region. Jbel M, et al. Eukaryot Cell, 2009 Apr. PMID 19252122, Free PMC Article
    3. The Schizosaccharomyces pombe corepressor Tup11 interacts with the iron-responsive transcription factor Fep1. Znaidi S, et al. J Biol Chem, 2004 Mar 5. PMID 14668334
    4. Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast. Kim KD, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531205
    5. Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. Pelletier B, et al. J Biol Chem, 2005 Jul 1. PMID 15866870

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal.
      Title: Iron homeostasis proteins Grx4 and Fra2 control activity of the Schizosaccharomyces pombe iron repressor Fep1 by facilitating [2Fe-2S] cluster removal.
    2. Grx4 independently governs the Php4 and Fep1 repressors through metal transfer. total or partial disassembly of the Grx4-Fra2 cluster actively participates in iron-containing Fep1 activation
      Title: A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast.
    3. Results describe the first example of a monothiol glutaredoxin (Grx4)that acts as an inhibitory partner for an iron-regulated transcription factor (fep1)under conditions of low iron levels.
      Title: Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.
    4. These results suggest that the ability of Grx4 to bind iron, most likely Fe-S cofactor, could be critical in interacting with and modulating the activity of Fep1.
      Title: Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast.
    5. The N-terminal region of Fep1 is able to activate its transcription in response to iron.
      Title: Iron activates in vivo DNA binding of Schizosaccharomyces pombe transcription factor Fep1 through its amino-terminal region.
    6. Novel regulatory targets were identified in Schizosaccharomyces pombe for Cuf1p (pex7 and SPAC3G6.05) and Fep1p (srx1, sib1, sib2, rds1, isu1, SPBC27B12.03c, SPAC1F8.02c, and SPBC947.05c).
      Title: Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.
    7. Fep1 is a non-canonical GATA factor required for iron homeostasis
      Title: Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ferrichrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Fe-sensing transcription factor Fep1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      442221..445721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018337.3 → NP_592936.1  Fe-sensing transcription factor Fep1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592936.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10134
      Conserved Domains (2) summary
      COG5641
      Location:16 → 555
      GAT1; GATA Zn-finger-containing transcription factor [Transcription]
      cd00202
      Location:171 → 222
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous