Cd59b CD59b molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd59bprovided by RGD
Official Full Name: CD59b moleculeprovided by RGD
Primary source: RGD:2311
See related: EnsemblRapid:ENSRNOG00000042821 AllianceGenome:RGD:2311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cd59; Cd59a; MACIF; MACIP; MAC-IP
Summary: Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1076.9), Heart (RPKM 717.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (110914008..110932489)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (90459085..90477571)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (94010481..94028660)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity.
Title: Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity.
study thus proposes the previously undescribed existence of non-GPI-anchored cytosolic CD59, which is required for insulin secretion.
Title: A cryptic non-GPI-anchored cytosolic isoform of CD59 controls insulin exocytosis in pancreatic β-cells by interaction with SNARE proteins.
Study generated CD59(-/-) rats to investigate the role of CD59 in neuromyelitis optica spectrum disorders (NMO) and to create NMO pathology by passive transfer of AQP4-IgG. Results implicate an important role of CD59 in modulating NMO pathology in rats and demonstrate amplification of AQP4-IgG-induced NMO disease with CD59 knockout.
Title: Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.
Organ injury in neuromyelitis optica (NMO) seropositive CD59(-/-) rats was prevented by a complement inhibitor. Significant pathological changes in seropositive CD59(-/-) rats were not seen in optic nerve, spinal cord or brain, including circumventricular tissue. Results implicate a major protective role of CD59 outside of the central nervous system in seropositive NMO.
Title: Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G.
In rats, CD59 and DAF genes are related to the negative effect of sulfasalazine on sperm maturation.
Title: Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine.
generation of recombinant form and examination of efficient and specific inhibition of membrane attack complex activity in vivo
Title: Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo.
Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis.
Title: Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd59a (e-PCR), detects polymorphism
- UniSTS:548001

BF403416 (e-PCR)
- UniSTS:246446

D3Wox16 (e-PCR)
- UniSTS:518903

RH127373 (e-PCR)
- UniSTS:210683

RH140857 (e-PCR)
- UniSTS:210683

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables complement binding	IBA Inferred from Biological aspect of Ancestor more info
enables complement binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activation of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activation of membrane attack complex	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement-dependent cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of complement activation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in compact myelin	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CD59 glycoprotein

Names: CD59 antigen; CD59 molecule, complement regulatory protein; CD59b moleucle, complement regulatory protein; Cb59b molecule; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012925.2 → NP_037057.1 CD59 glycoprotein precursor

See identical proteins and their annotated locations for NP_037057.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P27274

UniProtKB/TrEMBL

A0A8I6AF42, A6HNT4

Related

ENSRNOP00000060967.2, ENSRNOT00000067085.5

Conserved Domains (1) summary

smart00134
Location:23 → 97

LU; Ly-6 antigen / uPA receptor -like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

110914008..110932489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104371.2 → XP_038960299.1 CD59 glycoprotein isoform X2

Related

ENSRNOP00000082990.2, ENSRNOT00000111042.2

Conserved Domains (1) summary

cl10471
Location:23 → 64

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
XM_039104370.2 → XP_038960298.1 CD59 glycoprotein isoform X1

UniProtKB/Swiss-Prot

P27274

UniProtKB/TrEMBL

A0A8I6AF42, A6HNT4

Related

ENSRNOP00000092965.1, ENSRNOT00000103453.2

Conserved Domains (1) summary

smart00134
Location:23 → 97

LU; Ly-6 antigen / uPA receptor -like domain