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    shk1 PAK-like kinase Shk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539997, updated on 18-Sep-2024

    Summary

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    Official Symbol
    shk1
    Official Full Name
    PAK-like kinase Shk1
    Primary source
    PomBase:SPBC1604.14c
    Locus tag
    SPOM_SPBC1604.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    orb2; pak1
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    Genomic context

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    See shk1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3904616..3907593)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene G-patch type RNA-binding protein Neighboring gene pig-T family GPI synthesis protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein bL32m

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback. Harrell MA, et al. J Cell Biol, 2024 Sep 2. PMID 39012625, Free PMC Article
    2. Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis. Magliozzi JO, et al. J Cell Biol, 2020 Aug 3. PMID 32421151, Free PMC Article
    3. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. Ottilie S, et al. EMBO J, 1995 Dec 1. PMID 8846783, Free PMC Article
    4. Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle. Verde F, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636183, Free PMC Article
    5. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Marcus S, et al. Proc Natl Acad Sci U S A, 1995 Jun 20. PMID 7597098, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pak1 kinase controls cell shape through ribonucleoprotein granules.
      Title: Pak1 kinase controls cell shape through ribonucleoprotein granules.
    2. Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.
      Title: Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.
    3. Phosphorylation of the Myo1 TEDS site by Pak1 and Nak1 plays a crucial role in regulating Myo1 localisation and cellular function.
      Title: Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.
    4. Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin II regulatory light chain (Rlc1p) to inhibit cytokinesis.
      Title: Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic actomyosin contractile ring contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of establishment of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of maintenance of bipolar cell polarity regulating cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cytokinesis, division site positioning EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in positive regulation of pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cdc42 GTPase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic actomyosin contractile ring EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PAK-like kinase Shk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3904616..3907593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022547.3 → NP_596626.1  PAK-like kinase Shk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596626.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P50527
      Conserved Domains (3) summary
      smart00220
      Location:391 → 637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06614
      Location:385 → 638
      STKc_PAK; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase
      pfam00786
      Location:146 → 200
      PBD; P21-Rho-binding domain
    Nucleotide Protein
    Heading Accession and Version

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