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    psk1 serine/threonine protein kinase S6K family Psk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539494, updated on 18-Sep-2024

    Summary

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    Official Symbol
    psk1
    Official Full Name
    serine/threonine protein kinase S6K family Psk1
    Primary source
    PomBase:SPCC4G3.08
    Locus tag
    SPOM_SPCC4G3.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See psk1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (457709..459495, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA repair protein Rhp42 Neighboring gene ncRNA Neighboring gene GTPase-activating protein Gyp3 Neighboring gene ncRNA Neighboring gene PHD finger domain-containing protein Phf1 Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein uL29m

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast TOR complex 1 phosphorylates Psk1 through an evolutionarily conserved interaction mediated by the TOS motif. Morozumi Y, et al. J Cell Sci, 2021 Oct 1. PMID 34499159, Free PMC Article
    2. Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast. Madrid M, et al. Sci Rep, 2016 Nov 23. PMID 27876895, Free PMC Article
    3. Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase. Nakashima A, et al. J Cell Sci, 2012 Dec 1. PMID 22976295, Free PMC Article
    4. Global coordination of transcriptional control and mRNA decay during cellular differentiation. Amorim MJ, et al. Mol Syst Biol, 2010 Jun 8. PMID 20531409, Free PMC Article
    5. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results provide convincing evidence that /Psk1/Rps6 constitutes a nutrient-dependent signaling pathway in fission yeast.
      Title: Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC1 signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic translation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase S6K family Psk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      457709..459495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022823.3 → NP_587830.1  serine/threonine protein kinase S6K family Psk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587830.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O00044, Q12706
      Conserved Domains (3) summary
      smart00133
      Location:351 → 418
      S_TK_X; Extension to Ser/Thr-type protein kinases
      smart00220
      Location:91 → 335
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05123
      Location:97 → 350
      STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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