Atp5if1 ATP synthase inhibitory factor subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp5if1provided by RGD
Official Full Name: ATP synthase inhibitory factor subunit 1provided by RGD
Primary source: RGD:2181
See related: EnsemblRapid:ENSRNOG00000013300 AllianceGenome:RGD:2181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atpi; IF1PA; Atpif1
Summary: Enables ATPase inhibitor activity. Predicted to be involved in several processes, including mitochondrial depolarization; negative regulation of mitochondrial ATP synthesis coupled proton transport; and positive regulation of type 2 mitophagy. Predicted to act upstream of or within positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and reactive oxygen species metabolic process. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 915.9), Heart (RPKM 827.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (150022960..150026677, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144738950..144742668, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150719570..150723287, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced astrocyte injury in vitro: A rat model of ischemic brain injury.
Title: ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced astrocyte injury in vitro: A rat model of ischemic brain injury.
Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells.
Title: Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells.
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIdelta.
Title: ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.
Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells.
Title: Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells.
results indicate that IF1 is a negative regulator of insulin secretion involved in pancreatic beta-cell glucose sensing.
Title: Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1).
These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience
Title: Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.
The subunit c of F0F1-ATPase is a structural and/or regulatory component of the mPTP complex, whose activity might be modulated bycalcium-dependent phosphorylation.
Title: Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening.
Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Title: Hypoxia-inducible factor 1α regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis.
Title: Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Title: The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Atpif1 (e-PCR), detects polymorphism
- UniSTS:498299

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ATPase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables angiostatin binding	ISO Inferred from Sequence Orthology more info
enables angiostatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitochondrial proton-transporting ATP synthase complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP-dependent activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial ATP synthesis coupled proton transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 mitophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATPase inhibitor, mitochondrial

Names: ATP synthase F1 subunit epsilon; ATPase inhibitor (rat mitochondrial IF1 protein); ATPase inhibitory factor 1; IF(1); IF1; inhibitor of F(1)F(o)-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.