Actg2 actin gamma 2, smooth muscle [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Actg2provided by RGD
Official Full Name: actin gamma 2, smooth muscleprovided by RGD
Primary source: RGD:2027
See related: EnsemblRapid:ENSRNOG00000029401 AllianceGenome:RGD:2027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SMGA; ACTGE
Summary: Predicted to enable ATP binding activity; hydrolase activity; and protein kinase binding activity. Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Predicted to be located in several cellular components, including filopodium; lamellipodium; and myosin filament. Predicted to be part of protein-containing complex. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human ACTG2 (actin gamma 2, smooth muscle). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 1423.3) and Lung (RPKM 170.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117579513..117604379, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (116021832..116046475, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (115215160..115239746, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assessment of renal fibrosis in a rat model of unilateral ureteral obstruction with diffusion kurtosis imaging: Comparison with alpha-SMA expression and (18)F-FDG PET.
Title: Assessment of renal fibrosis in a rat model of unilateral ureteral obstruction with diffusion kurtosis imaging: Comparison with α-SMA expression and (18)F-FDG PET.
Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1
Title: Hepatocyte growth factor-induced amelioration in renal interstitial fibrosis is associated with reduced expression of alpha-smooth muscle actin and transforming growth factor-beta1.
PPAR gamma expression increases in rat renal tissue after unilateral ureteral obstruction but does not always correlate with alpha-smooth muscle actin expression.
Title: [Expression of peroxisome proliferators-activated receptor gamma and alpha-smooth muscle actin in unilateral ureteral obstruction in rats].
MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter
Title: Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.
Thus, these data support a functional link between REMS and cytoskeletal reorganization in the hippocampus, a process that is essential for synaptic plasticity.
Title: REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity.
Actin cytoskeleton disassembly diminishes size of endocytic events. Important role in determining size of endocytic vesicles. Coupling between exocytosis and endocytosis independent of state of actin cytoskeleton.
Title: Distinct effect of actin cytoskeleton disassembly on exo- and endocytic events in a membrane patch of rat melanotrophs.
The localization of gamma-actin was markedly altered during pregnancy.
Title: Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium.
demonstrate the alterations of alpha-smooth muscle actin and vimentin localization patterns in the bovine cryptorchid testis as compared to the contralateral scrotal testis during postnatal development.
Title: Alterations in the immunohistochemical localization patterns of alpha-smooth muscle actin (SMA) and vimentin in the postnatally developing bovine cryptorchid testis.
conclude that force-induced p38 phosphorylation is dependent on an SMGA filament-dependent pathway that uses a feed-forward amplification loop to synergize force-induced SMGA expression with p38 activation
Title: Smooth muscle actin determines mechanical force-induced p38 activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS_ADH2 (e-PCR)
- UniSTS:470621

GVL|STS_ADH2 (e-PCR)
- UniSTS:470621

PMC20960P1 (e-PCR)
- UniSTS:272003

PMC305873P2 (e-PCR)
- UniSTS:272568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in glomerular mesangial cell development	IEA Inferred from Electronic Annotation more info
involved_in mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in myosin filament	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: actin, gamma-enteric smooth muscle

Names: actin, gamma 2, smooth muscle, enteric; alpha-actin-3; alpha-smooth muscle actin; gamma-2-actin; gamma-enteric smooth muscle actin; smooth muscle gamma-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012893.1 → NP_037025.1 actin, gamma-enteric smooth muscle

See identical proteins and their annotated locations for NP_037025.1

Status: PROVISIONAL

Source sequence(s)

M22323

UniProtKB/Swiss-Prot

P63269

UniProtKB/TrEMBL

A0A0G2K4M6, A6IAN1

Conserved Domains (1) summary

PTZ00281
Location:1 → 376

PTZ00281; actin; Provisional