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    Dcc DCC netrin 1 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25311, updated on 2-Nov-2024

    Summary

    Official Symbol
    Dccprovided by RGD
    Official Full Name
    DCC netrin 1 receptorprovided by RGD
    Primary source
    RGD:2492
    See related
    EnsemblRapid:ENSRNOG00000033099 AllianceGenome:RGD:2492
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including nervous system development; positive regulation of ERK1 and ERK2 cascade; and response to amphetamine. Located in growth cone membrane. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 45.8) See more
    Orthologs
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    Genomic context

    See Dcc in Genome Data Viewer
    Location:
    18q12.1-q12.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (67144272..68248159, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64868987..65972783, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (66518213..67629801, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 149 like 1 Neighboring gene high mobility group AT-hook 1, pseudogene 1 Neighboring gene ribosomal protein L37, pseudogene 3 Neighboring gene uncharacterized LOC108348868 Neighboring gene uncharacterized LOC120098154 Neighboring gene uncharacterized LOC134483048 Neighboring gene uncharacterized LOC134482987

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables netrin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anterior/posterior axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in corpus callosum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dorsal/ventral axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dorsal/ventral axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in netrin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in optic nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spinal cord ventral commissure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spinal cord ventral commissure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    netrin receptor DCC
    Names
    colorectal tumor suppressor
    deleted in colorectal carcinoma
    putative colorectal tumor suppressor
    tumor suppressor protein DCC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012841.2NP_036973.1  netrin receptor DCC precursor

      See identical proteins and their annotated locations for NP_036973.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      Q63155
      UniProtKB/TrEMBL
      F1LRN5
      Related
      ENSRNOP00000063072.4, ENSRNOT00000064947.5
      Conserved Domains (8) summary
      cd05722
      Location:42136
      Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
      smart00408
      Location:153219
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:726805
      FN3; Fibronectin type 3 domain
      smart00410
      Location:147224
      IG_like; Immunoglobulin like
      cd00063
      Location:528617
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:241327
      I-set; Immunoglobulin I-set domain
      pfam06583
      Location:11481443
      Neogenin_C; Neogenin C-terminus
      cl11960
      Location:347417
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      67144272..68248159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772087.4XP_008770309.2  netrin receptor DCC isoform X3

      UniProtKB/TrEMBL
      A0A8I6ATC8, F1LRN5
      Related
      ENSRNOP00000096451.1, ENSRNOT00000101171.2
    2. XM_063277120.1XP_063133190.1  netrin receptor DCC isoform X5

    3. XM_063277119.1XP_063133189.1  netrin receptor DCC isoform X4

    4. XM_063277122.1XP_063133192.1  netrin receptor DCC isoform X7

    5. XM_063277121.1XP_063133191.1  netrin receptor DCC isoform X6

      Related
      ENSRNOP00000102890.1, ENSRNOT00000124479.1
    6. XM_063277118.1XP_063133188.1  netrin receptor DCC isoform X2

    7. XM_039096588.2XP_038952516.2  netrin receptor DCC isoform X1

      Related
      ENSRNOP00000101128.1, ENSRNOT00000150851.1
    8. XM_039096590.2XP_038952518.1  netrin receptor DCC isoform X8

      Conserved Domains (3) summary
      smart00060
      Location:230309
      FN3; Fibronectin type 3 domain
      cd00063
      Location:32121
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06583
      Location:652949
      Neogenin_C; Neogenin C-terminus