Saxo4 stabilizer of axonemal microtubules 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Saxo4provided by RGD
Official Full Name: stabilizer of axonemal microtubules 4provided by RGD
Primary source: RGD:708532
See related: EnsemblRapid:ENSRNOG00000020620 AllianceGenome:RGD:708532
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Iiig9; Ppp1r32
Summary: Predicted to enable phosphatase binding activity. Predicted to be involved in flagellated sperm motility. Located in cilium and cytoplasm. Orthologous to human SAXO4 (stabilizer of axonemal microtubules 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 260.0) and Lung (RPKM 18.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216538735..216548195, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207113807..207122378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226518405..226527903, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
Title: IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
IIIG9 is localized in the cilia of adult ependymal cells and that its expression is correlated with the process of ependymal differentiation and with the maturation of radial glia.
Title: Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.
IIIG9 mRNA is expressed along brain ventricles
Title: A novel mRNA expressed along brain ventricles.

Submit: New GeneRIF Correction

General gene information

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Markers

D12S1329 (e-PCR)
- UniSTS:32813

NoName (e-PCR)
- UniSTS:488764

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	ISO Inferred from Sequence Orthology more info
is_active_in axonemal A tubule inner sheath	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: stabilizer of axonemal microtubules 4

Names: protein phosphatase 1, regulatory subunit 32; uncharacterized protein C11orf66 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145786.1 → NP_665729.1 stabilizer of axonemal microtubules 4

See identical proteins and their annotated locations for NP_665729.1

Status: PROVISIONAL

Source sequence(s)

AY032665

UniProtKB/Swiss-Prot

Q66HR9, Q91XJ3, Q91XJ4

UniProtKB/TrEMBL

A6I033

Related

ENSRNOP00000028003.2, ENSRNOT00000028003.5

Conserved Domains (1) summary

pfam15691
Location:2 → 416

PPP1R32; Protein phosphatase 1 regulatory subunit 32

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216538735..216548195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281660.1 → XP_063137730.1 stabilizer of axonemal microtubules 4 isoform X1

UniProtKB/TrEMBL

A6I034
XM_006231016.5 → XP_006231078.1 stabilizer of axonemal microtubules 4 isoform X1

See identical proteins and their annotated locations for XP_006231078.1

UniProtKB/Swiss-Prot

Q66HR9, Q91XJ3, Q91XJ4

UniProtKB/TrEMBL

A6I033, A6I034

Conserved Domains (1) summary

pfam15691
Location:1 → 372

PPP1R32; Protein phosphatase 1 regulatory subunit 32