U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Amacr alpha-methylacyl-CoA racemase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25284, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Amacrprovided by RGD
    Official Full Name
    alpha-methylacyl-CoA racemaseprovided by RGD
    Primary source
    RGD:3048
    See related
    EnsemblRapid:ENSRNOG00000018662 AllianceGenome:RGD:3048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Da1-8; Marc1
    Summary
    Enables alpha-methylacyl-CoA racemase activity. Involved in bile acid biosynthetic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in alpha-methylacyl-CoA racemase deficiency; congenital bile acid synthesis defect 4; and urinary bladder cancer. Orthologous to human AMACR (alpha-methylacyl-CoA racemase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 1549.5), Kidney (RPKM 1198.5) and 2 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Amacr in Genome Data Viewer
    Location:
    2q16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61673291..61685381)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59946158..59958255)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60949276..60961342)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene C1q and TNF related 3 Neighboring gene solute carrier family 45, member 2 Neighboring gene relaxin family peptide receptor 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer. Honma I, et al. J Transl Med, 2009 Dec 9. PMID 20003233, Free PMC Article
    2. Expression of alpha-methylacyl-CoA racemase correlates with histopathologic grading in noninvasive bladder cancer. Gunia S, et al. Virchows Arch, 2008 Aug. PMID 18648853
    3. Purification and properties of an alpha-methylacyl-CoA racemase from rat liver. Schmitz W, et al. Eur J Biochem, 1994 Jun 1. PMID 8020470
    4. Prognostic significance of alpha-methylacyl-coA racemase among men with high grade prostatic intraepithelial neoplasia in prostate biopsies. Stewart J, et al. J Urol, 2008 May. PMID 18343427
    5. Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression. Langner C, et al. Virchows Arch, 2006 Mar. PMID 16315020

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role of alpha-methylacyl-CoA racemase in bile acid synthesis
      Title: The role of alpha-methylacyl-CoA racemase in bile acid synthesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-methylacyl-CoA racemase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-methylacyl-CoA racemase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-methylacyl-CoA racemase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-methylacyl-CoA racemase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bile acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bile acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bile acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-methylacyl-CoA racemase
    Names
    2-arylpropionyl-CoA epimerase
    2-methylacyl-CoA racemase
    NP_036948.2
    XP_038957703.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012816.2 → NP_036948.2  alpha-methylacyl-CoA racemase

      See identical proteins and their annotated locations for NP_036948.2

      Status: VALIDATED

      Source sequence(s)
      BC127505, FM061736
      UniProtKB/Swiss-Prot
      O09176, P70473
      UniProtKB/TrEMBL
      A6KJS2, G3V8F9
      Related
      ENSRNOP00000025323.3, ENSRNOT00000025323.7
      Conserved Domains (1) summary
      COG1804
      Location:3 → 373
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      61673291..61685381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101775.2 → XP_038957703.1  alpha-methylacyl-CoA racemase isoform X1

      Conserved Domains (1) summary
      COG1804
      Location:3 → 185
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70473.3 GenPept UniProtKB/Swiss-Prot:P70473

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools