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    Il4r interleukin 4 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25084, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Il4rprovided by RGD
    Official Full Name
    interleukin 4 receptorprovided by RGD
    Primary source
    RGD:2899
    See related
    EnsemblRapid:ENSRNOG00000015441 AllianceGenome:RGD:2899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Il4ra
    Summary
    Predicted to enable interleukin-4 receptor activity. Involved in regulation of cell population proliferation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 136.5), Adrenal (RPKM 114.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il4r in Genome Data Viewer
    Location:
    1q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (189545739..189570639)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180115061..180139981)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (196942343..196967221)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 8 Neighboring gene NSE1 homolog, SMC5-SMC6 complex component Neighboring gene uncharacterized LOC103691233 Neighboring gene uncharacterized LOC120097359 Neighboring gene interleukin 21 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Asthma susceptible genes in Chinese population: a meta-analysis. Li X, et al. Respir Res, 2010 Sep 24. PMID 20868478, Free PMC Article
    2. IL-4 induces IL-13-independent allergic airway inflammation. Perkins C, et al. J Allergy Clin Immunol, 2006 Aug. PMID 16890766
    3. Elevated serum levels of soluble interleukin-4 receptor in osteoarthritis. Silvestri T, et al. Osteoarthritis Cartilage, 2006 Jul. PMID 16647277
    4. IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I: up-regulation of muscle IL-15 by IL-4. Shandley S, et al. Clin Immunol, 2009 Aug. PMID 19395316, Free PMC Article
    5. Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Limer KL, et al. Osteoarthritis Cartilage, 2009 Jun. PMID 19036616

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results suggest that oxidative stress may up-regulate IL-4 gene expression in mast cells via a decrease in HDAC activity.
      Title: Oxidative stress regulates IL-4 gene expression in mast cells through the reduction of histone deacetylase.
    2. In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only.
      Title: Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus.
    3. Data show that IL-4 receptors are functionally competent in pancreatic beta-cells and that they signal via PI3K and JAK/STAT pathways.
      Title: Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways.
    4. Increased of IL4Ra in glomeruli in induced Minimal change-like nephropathy.
      Title: Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-4 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-4 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-4-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in production of molecular mediator involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to odorant IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-4 receptor subunit alpha
    Names
    IL-4 receptor subunit alpha
    IL-4R subunit alpha
    IL-4R-alpha
    IL-4RA
    interleukin 4 receptor, alpha
    interleukin-4 receptor alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133380.2 → NP_596871.2  interleukin-4 receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_596871.2

      Status: VALIDATED

      Source sequence(s)
      AB015747, AW527353, BQ204155
      UniProtKB/Swiss-Prot
      Q63257, Q9R1W8, Q9WTM8
      UniProtKB/TrEMBL
      A0A8L2R7Z3, A6I914
      Related
      ENSRNOP00000073767.3, ENSRNOT00000088073.3
      Conserved Domains (2) summary
      cd00063
      Location:123 → 220
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09238
      Location:32 → 121
      IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      189545739..189570639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230215.5 → XP_006230277.1  interleukin-4 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006230277.1

      UniProtKB/Swiss-Prot
      Q63257, Q9R1W8, Q9WTM8
      UniProtKB/TrEMBL
      A0A8L2R7Z3, A6I914
      Related
      ENSRNOP00000020994.2, ENSRNOT00000020994.7
      Conserved Domains (2) summary
      cd00063
      Location:123 → 220
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09238
      Location:32 → 121
      IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

    2. XM_006230216.4 → XP_006230278.1  interleukin-4 receptor subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006230278.1

      UniProtKB/Swiss-Prot
      Q63257, Q9R1W8, Q9WTM8
      UniProtKB/TrEMBL
      A0A8L2R7Z3, A6I914
      Conserved Domains (2) summary
      cd00063
      Location:123 → 220
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09238
      Location:32 → 121
      IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal

    3. XM_017588804.3 → XP_017444293.1  interleukin-4 receptor subunit alpha isoform X1

      UniProtKB/Swiss-Prot
      Q63257, Q9R1W8, Q9WTM8
      UniProtKB/TrEMBL
      A0A8L2R7Z3, A6I914
      Conserved Domains (2) summary
      cd00063
      Location:123 → 220
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam09238
      Location:32 → 121
      IL4Ra_N; Interleukin-4 receptor alpha chain, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63257.2 GenPept UniProtKB/Swiss-Prot:Q63257

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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