Rnf112 ring finger protein 112 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf112provided by RGD
Official Full Name: ring finger protein 112provided by RGD
Primary source: RGD:3986
See related: EnsemblRapid:ENSRNOG00000002364 AllianceGenome:RGD:3986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BFP; Bfb; Zfp179; Znf179
Summary: Predicted to enable GTP binding activity; GTPase activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including embryonic brain development; protein autoubiquitination; and protein homooligomerization. Predicted to act upstream of or within G1 to G0 transition involved in cell differentiation; positive regulation of glial cell differentiation; and positive regulation of neuron differentiation. Predicted to be located in several cellular components, including cytoplasmic vesicle; nuclear body; and postsynaptic density. Orthologous to human RNF112 (ring finger protein 112). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 187.5), Lung (RPKM 11.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46620602..46655745, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46121146..46126691, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47719034..47726050, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify neurolastin as a dynamin family GTPase that affects endosome size and spine density.
Title: Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G1 to G0 transition involved in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G1 to G0 transition involved in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	IEA Inferred from Electronic Annotation more info
involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in response to hydroperoxide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: RING finger protein 112

Names: brain finger protein; zinc finger protein 179

NP_619516.1

EC 2.3.2.27

XP_063124516.1

EC 2.3.2.27

XP_063124517.1

EC 2.3.2.27

XP_063124518.1

EC 2.3.2.27

XP_063124519.1

EC 2.3.2.27

XP_063124520.1

EC 2.3.2.27

XP_063124521.1

EC 2.3.2.27

XP_063124522.1

EC 2.3.2.27

XP_063124523.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430037.1 → NP_001416966.1 RING finger protein 112 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_138613.3 → NP_619516.1 RING finger protein 112 isoform 1

See identical proteins and their annotated locations for NP_619516.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O70418

UniProtKB/TrEMBL

A6HF79

Conserved Domains (2) summary

cd01851
Location:163 → 394

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd00162
Location:56 → 101

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...