Plaat3 phospholipase A and acyltransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plaat3provided by RGD
Official Full Name: phospholipase A and acyltransferase 3provided by RGD
Primary source: RGD:2829
See related: EnsemblRapid:ENSRNOG00000021206 AllianceGenome:RGD:2829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HRSL3; RLP-3; Hrasls3; Hrev107; Pla2g16
Summary: Enables phospholipase A1 activity and phospholipase A2 activity. Involved in negative regulation of cell cycle. Predicted to be located in several cellular components, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Predicted to be active in cytoplasm. Orthologous to human PLAAT3 (phospholipase A and acyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 178.9), Thymus (RPKM 132.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (214211755..214245551)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204782608..204816397)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222844238..222877180)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylphosphatidylethanolamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ether lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ether lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in membrane disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle disassembly	ISO Inferred from Sequence Orthology more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in regulation of adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A and acyltransferase 3

Names: H-rev 107 protein homolog; HRAS-like suppressor 3; Hras-revertant gene 107 (expression down-regulated in HRAS-transformed rat 208F fibroblasts); LRAT-like protein-3; group XVI phospholipase A1/A2; group XVI phospholipase A2; phospholipase A2, group XVI

NP_058756.2

EC 3.1.1.32

EC 3.1.1.4

XP_006230749.1

EC 3.1.1.32

EC 3.1.1.4

XP_038957032.1

EC 3.1.1.32

EC 3.1.1.4

XP_038957036.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017060.2 → NP_058756.2 phospholipase A and acyltransferase 3

See identical proteins and their annotated locations for NP_058756.2

Status: VALIDATED

Source sequence(s)

CB613004, CB794299

UniProtKB/Swiss-Prot

B7X6T2, P53817

UniProtKB/TrEMBL

A0A8L2QJ20

Related

ENSRNOP00000038045.4, ENSRNOT00000032879.7

Conserved Domains (1) summary

pfam04970
Location:17 → 123

LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

214211755..214245551

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101108.2 → XP_038957036.1 phospholipase A and acyltransferase 3 isoform X3

Conserved Domains (1) summary

pfam04970
Location:1 → 75

LRAT; Lecithin retinol acyltransferase
XM_039101104.2 → XP_038957032.1 phospholipase A and acyltransferase 3 isoform X2

UniProtKB/Swiss-Prot

B7X6T2, P53817

UniProtKB/TrEMBL

A0A8L2QJ20

Conserved Domains (1) summary

pfam04970
Location:17 → 123

LRAT; Lecithin retinol acyltransferase
XM_006230687.5 → XP_006230749.1 phospholipase A and acyltransferase 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JTD0, A0A8L2QJ20

Related

ENSRNOP00000105263.1, ENSRNOT00000163362.1

Conserved Domains (1) summary

pfam04970
Location:46 → 152

LRAT; Lecithin retinol acyltransferase