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    Tcrb T-cell receptor beta chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24820, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tcrbprovided by RGD
    Official Full Name
    T-cell receptor beta chainprovided by RGD
    Primary source
    RGD:3834
    See related
    AllianceGenome:RGD:3834
    Gene type
    protein coding
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TCB; TCBC1; RATTCB; RATTCBC1
    Summary
    Involved in cellular defense response. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    4q22

    Bibliography

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    Related articles in PubMed

    1. Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus. Mordes JP, et al. Mamm Genome, 2009 Mar. PMID 19205800, Free PMC Article
    2. Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene. Blankenhorn EP, et al. Ann N Y Acad Sci, 2007 Apr. PMID 17376830
    3. Tracking of V beta 8.2-positive encephalitogenic T cells by complementarity-determining region 3 spectratyping and subsequent Southern blot hybridization in Lewis rats after neuroantigen sensitization. Sakuma H, et al. J Immunol, 2004 Oct 1. PMID 15383583
    4. Alleles of highly homologous rat T cell receptor beta-chain variable segments 8.2 and 8.4: strain-specific expression, reactivity to superantigens, and binding of the mAb R78. Asmuss A, et al. J Immunol, 1996 Nov 15. PMID 8906819
    5. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. Burns FR, et al. J Exp Med, 1989 Jan 1. PMID 2462609, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.
      Title: T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.
    2. Tcrb-V13 SNPs is critical for autoimmune diabetes in rats.
      Title: Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
    3. T cell receptor beta chain variable 4 region (TCRVbeta4) may be protective against diabetes mellitus
      Title: Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
    4. Encephalitogenic T cells of Lewis rats with myelin basic protein-induced experimental autoimmune encephalomyelitis (EAE) mainly use V beta 8.2 T cell receptors (TCRs) containing the EAE-specific complementarity-determining region 3 (CDR3).
      Title: Tracking of V beta 8.2-positive encephalitogenic T cells by complementarity-determining region 3 spectratyping and subsequent Southern blot hybridization in Lewis rats after neuroantigen sensitization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Other Names

    • T-cell receptor beta cluster
    • variable region-beta 8.5

    Clone Names

    • MGC108929, MGC109620, MGC116333

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Names
    T-cell receptor beta chain
    T-cell receptor beta cluster
    variable region-beta 8.5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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