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    Cyp4x1 cytochrome P450, family 4, subfamily x, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246767, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cyp4x1provided by RGD
    Official Full Name
    cytochrome P450, family 4, subfamily x, polypeptide 1provided by RGD
    Primary source
    RGD:628719
    See related
    EnsemblRapid:ENSRNOG00000043513 AllianceGenome:RGD:628719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable anandamide 14,15 epoxidase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to several human genes including CYP4X1 (cytochrome P450 family 4 subfamily X member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 67.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyp4x1 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (133888439..133923254, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (128651681..128683338, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (133929532..133959447, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102952 Neighboring gene PDZK1 interacting protein 1 Neighboring gene transfer RNA proline (anticodon AGG) 66 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 8 Neighboring gene MCTS1, re-initiation and release factor, pseudogene 1 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 8, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature. Carver KA, et al. Am J Physiol Cell Physiol, 2014 Dec 1. PMID 25055826, Free PMC Article
    2. Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. Stark K, et al. FEBS J, 2008 Jul. PMID 18549450, Free PMC Article
    3. Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Bylund J, et al. Biochem Biophys Res Commun, 2002 Aug 23. PMID 12176035
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest there is circadian regulation of Cyp4x1 and Cyp2c11 gene expression, and that eicosanoid production may contribute to circadian changes in blood flow and alter the risk of adverse cardiovascular events throughout the day.
      Title: Rhythmic expression of cytochrome P450 epoxygenases CYP4x1 and CYP2c11 in the rat brain and vasculature.
    2. molecular cloning & specific localization of Cyp4x1 to the brain
      Title: Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4X1
    Names
    CYPIVX1
    NP_663708.1
    XP_063143232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145675.2 → NP_663708.1  cytochrome P450 4X1

      See identical proteins and their annotated locations for NP_663708.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8K4D6
      UniProtKB/TrEMBL
      A6JZ35, A6JZ36
      Related
      ENSRNOP00000011985.1, ENSRNOT00000011985.4
      Conserved Domains (1) summary
      cd20678
      Location:66 → 500
      CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      133888439..133923254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287162.1 → XP_063143232.1  cytochrome P450 4X1 isoform X1

    RNA

    1. XR_005504366.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4D6.1 GenPept UniProtKB/Swiss-Prot:Q8K4D6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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