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    Pgm1 phosphoglucomutase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24645, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pgm1provided by RGD
    Official Full Name
    phosphoglucomutase 1provided by RGD
    Primary source
    RGD:3316
    See related
    EnsemblRapid:ENSRNOG00000009889 AllianceGenome:RGD:3316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphoglucomutase activity. Involved in cellular response to magnetism and glucose metabolic process. Located in Z disc. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation It; endometrial cancer; and teratoma. Orthologous to human PGM1 (phosphoglucomutase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 3276.7), Heart (RPKM 438.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgm1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (119710734..119770159)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (114595298..114654728)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118743632..118803055)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479015 Neighboring gene ALG6, alpha-1,3-glucosyltransferase Neighboring gene integrin subunit beta 3 binding protein Neighboring gene EF-hand calcium binding domain 7 Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 233

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and immunohistochemical localization of a chondroitin sulfate proteoglycan from adult rat brain. Normand G, et al. J Neurochem, 1988 Sep. PMID 3411319
    2. Differentiation of chromaffin cells elicited by ELF MF modifies gene expression pattern. Olivares-Bañuelos T, et al. Cell Biol Int, 2004. PMID 15109983
    3. Isolation and expression of a rat liver cDNA encoding phosphoglucomutase. Rivera AA, et al. Gene, 1993 Nov 15. PMID 8224913
    4. Long-term alcohol intake enhances ADP-ribosylation of the multifunctional enzyme, phosphoglucomutase, in rat liver. Nomura F, et al. Hepatology, 1996 Nov. PMID 8903405
    5. Induced Structural Disorder as a Molecular Mechanism for Enzyme Dysfunction in Phosphoglucomutase 1 Deficiency. Stiers KM, et al. J Mol Biol, 2016 Apr 24. PMID 26972339, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoglucomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglucomutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoglucomutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglucomutase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to magnetism IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in galactose catabolic process via UDP-galactose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglucomutase-1
    Names
    PGM 1
    glucose phosphomutase 1
    NP_058729.2
    XP_006238504.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429272.1 → NP_001416201.1  phosphoglucomutase-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AV00

    2. NM_001429273.1 → NP_001416202.1  phosphoglucomutase-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AV00

    3. NM_017033.3 → NP_058729.2  phosphoglucomutase-1 isoform 2

      See identical proteins and their annotated locations for NP_058729.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P38652
      UniProtKB/TrEMBL
      A6JRM5, F7F2L9, Q499Q4
      Related
      ENSRNOP00000013785.5, ENSRNOT00000013785.8
      Conserved Domains (2) summary
      cd03085
      Location:5 → 562
      PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
      PLN02307
      Location:1 → 562
      PLN02307; phosphoglucomutase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      119710734..119770159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238442.5 → XP_006238504.1  phosphoglucomutase-1 isoform X1

      Related
      ENSRNOP00000097832.1, ENSRNOT00000103908.2
      Conserved Domains (2) summary
      cd03085
      Location:24 → 580
      PGM1; Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, ...
      PLN02307
      Location:27 → 580
      PLN02307; phosphoglucomutase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38652.2 GenPept UniProtKB/Swiss-Prot:P38652

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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