U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Macrod1 mono-ADP ribosylhydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246233, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Macrod1provided by RGD
    Official Full Name
    mono-ADP ribosylhydrolase 1provided by RGD
    Primary source
    RGD:628701
    See related
    EnsemblRapid:ENSRNOG00000021174 AllianceGenome:RGD:628701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrp16
    Summary
    Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in mitochondrion and nucleus. Predicted to be active in nucleoplasm. Orthologous to human MACROD1 (mono-ADP ribosylhydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 1013.4), Heart (RPKM 655.5) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Macrod1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213675413..213831571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204246238..204387027)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222310916..222451485)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing kindlin 3 Neighboring gene tRNA phosphotransferase 1 Neighboring gene uncharacterized LOC120099981 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene fibronectin leucine rich transmembrane protein 1 Neighboring gene uncharacterized LOC108349688 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 1 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 2 Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene REST corepressor 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report. Han WD, et al. Endocr Relat Cancer, 2003 Jun. PMID 12790785
    2. A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Jankevicius G, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474712, Free PMC Article
    3. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Rosenthal F, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474714
    4. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342
    5. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. Chen D, et al. J Biol Chem, 2011 Apr 15. PMID 21257746, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-ribosylglutamate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein de-ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ADP-ribose glycohydrolase MACROD1
    Names
    MACRO domain containing 1
    MACRO domain-containing protein 1
    O-acetyl-ADP-ribose deacetylase MACROD1
    [Protein ADP-ribosylaspartate] hydrolase MACROD1
    [Protein ADP-ribosylglutamate] hydrolase
    [Protein ADP-ribosylglutamate] hydrolase MACROD1
    NP_647553.2
    XP_006230739.1
    XP_038955752.1
    XP_038955785.1
    XP_038955829.1
    XP_038955867.1
    XP_038955903.1
    XP_063137030.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139337.2 → NP_647553.2  ADP-ribose glycohydrolase MACROD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K5F1, A6HZN3
      Related
      ENSRNOP00000073401.1, ENSRNOT00000091465.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213675413..213831571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230677.5 → XP_006230739.1  ADP-ribose glycohydrolase MACROD1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AN55
      Related
      ENSRNOP00000097100.1, ENSRNOT00000106741.2
      Conserved Domains (2) summary
      COG2110
      Location:150 → 314
      YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
      cd02908
      Location:151 → 317
      Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

    2. XM_063280960.1 → XP_063137030.1  ADP-ribose glycohydrolase MACROD1 isoform X2

    3. XM_039099939.2 → XP_038955867.1  ADP-ribose glycohydrolase MACROD1 isoform X7

      Conserved Domains (1) summary
      cl00019
      Location:151 → 170
      Macro_SF; macrodomain superfamily

    4. XM_039099857.2 → XP_038955785.1  ADP-ribose glycohydrolase MACROD1 isoform X4

      Conserved Domains (1) summary
      cl00019
      Location:151 → 170
      Macro_SF; macrodomain superfamily

    5. XM_039099975.2 → XP_038955903.1  ADP-ribose glycohydrolase MACROD1 isoform X6

      Conserved Domains (1) summary
      cl00019
      Location:151 → 170
      Macro_SF; macrodomain superfamily

    6. XM_039099901.2 → XP_038955829.1  ADP-ribose glycohydrolase MACROD1 isoform X5

      Conserved Domains (1) summary
      cl00019
      Location:151 → 170
      Macro_SF; macrodomain superfamily

    7. XM_039099824.2 → XP_038955752.1  ADP-ribose glycohydrolase MACROD1 isoform X3

      Conserved Domains (1) summary
      cl00019
      Location:151 → 170
      Macro_SF; macrodomain superfamily

    RNA

    1. XR_010063054.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4G6.2 GenPept UniProtKB/Swiss-Prot:Q8K4G6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools