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    Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 246049, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc36a2provided by MGI
    Official Full Name
    solute carrier family 36 (proton/amino acid symporter), member 2provided by MGI
    Primary source
    MGI:MGI:1891430
    See related
    Ensembl:ENSMUSG00000020264 AllianceGenome:MGI:1891430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAT2; Tramd1; A530067G19Rik
    Summary
    Enables amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport and proton transmembrane transport. Located in endoplasmic reticulum membrane; plasma membrane; and recycling endosome membrane. Is expressed in several structures, including ear; face; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC36A2 (solute carrier family 36 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 166.7), subcutaneous fat pad adult (RPKM 116.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc36a2 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.16 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55049294..55075924, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55158468..55185099, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6987 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 3, opposite strand Neighboring gene predicted gene, 31688 Neighboring gene STARR-positive B cell enhancer ABC_E3952 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr11:55017598-55017899 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells. Zebisch K, et al. Amino Acids, 2013 Feb. PMID 22711289
    2. Association of PAT proteins with lipid storage droplets in term fetal membranes. Ackerman WE 4th, et al. Placenta, 2007 May-Jun. PMID 16965813
    3. Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2. Foltz M, et al. Eur J Biochem, 2004 Aug. PMID 15291811
    4. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. Rubio-Aliaga I, et al. J Biol Chem, 2004 Jan 23. PMID 14600155
    5. Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve. Bermingham JR Jr, et al. J Neurosci, 2002 Dec 1. PMID 12451123, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
      Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
    2. During the 14 day differentiation period the uptake of the prototype PAT2 substrate L-[(3)H]proline increased ~5-fold.
      Title: Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells.
    3. proton binding affinity to PAT2 is substrate-independent, favouring a sequential binding of proton followed by substrate
      Title: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2.
    4. Classification of lipid storage droplets based on this protein suggests that these organelles may serve specialized functions within individual cells.
      Title: Association of PAT proteins with lipid storage droplets in term fetal membranes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-alanine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables L-tyrosine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid:proton symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-alanine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of glycine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proline transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of proline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proton transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    proton-coupled amino acid transporter 2
    Names
    proton/amino acid transporter 2
    solute carrier family 36 member 2
    tramdorin 1 (transmembrane domain rich protein)
    tramdorin-1
    transmembrane domain rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153170.3 → NP_694810.2  proton-coupled amino acid transporter 2

      See identical proteins and their annotated locations for NP_694810.2

      Status: VALIDATED

      Source sequence(s)
      AK079053, AK086373, BB520081
      Consensus CDS
      CCDS24709.1
      UniProtKB/Swiss-Prot
      Q8BHK3, Q8BUB0, Q8JZP1
      Related
      ENSMUSP00000045613.6, ENSMUST00000039305.6
      Conserved Domains (1) summary
      cl00456
      Location:48 → 458
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      55049294..55075924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533324.5 → XP_006533387.1  proton-coupled amino acid transporter 2 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:48 → 426
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_006533325.5 → XP_006533388.1  proton-coupled amino acid transporter 2 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:7 → 321
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_030246005.2 → XP_030101865.1  proton-coupled amino acid transporter 2 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:1 → 396
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHK3.1 GenPept UniProtKB/Swiss-Prot:Q8BHK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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