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Myc MYC proto-oncogene, bHLH transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24577, updated on 14-Nov-2024

Summary

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Official Symbol: Mycprovided by RGD
Official Full Name: MYC proto-oncogene, bHLH transcription factorprovided by RGD
Primary source: RGD:3130
See related: EnsemblRapid:ENSRNOG00000004500 AllianceGenome:RGD:3130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mMyc; c-myc; RNCMYC
Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Spleen (RPKM 98.0), Thymus (RPKM 64.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Myc in Genome Data Viewer

Location:: 7q33

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (95483105..95488031)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (93593705..93598633)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (102586313..102591240)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptional activation of the Myc gene by glucose in beta-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.
Title: Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.
Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
Title: Correlation of Myc Expression with Wee1 Expression by Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.
Title: C-MYC ameliorates ventricular remodeling of myocardial infarction rats via binding to the promoter of microRNA-29a-3p to facilitate TET2 expression.
Role of Myc Proto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury.
Title: Role of Myc Proto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury.
Involvement of proliferative and apoptotic factors in the development of hindgut in rat fetuses with ethylenethiourea-induced anorectal malformations.
Title: Involvement of proliferative and apoptotic factors in the development of hindgut in rat fetuses with ethylenethiourea-induced anorectal malformations.
miR-449a-5p and Myc are involved in the hypoxic PAH by controlling metabolic pathways and phenotype of PASMCs leading to hyperproliferation. More importantly, miR-449a-5p/Myc axis, a novel molecular mechanism, is highlighted in the influence on mitochondrial function.
Title: MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells.
results suggested a mechanism by which c-myc facilitates the release of Muller Cells-derived proinflammatory cytokines by regulating MIAT/TXNIP pathway.
Title: C-myc contributes to the release of Müller cells-derived proinflammatory cytokines by regulating lncRNA MIAT/XNIP pathway.
PLCG2 plays an important role in rat liver cell proliferation via ERK and NF-kappaB pathway by regulating the expression of BCl2, MYC and CCND1
Title: PLCG2 promotes hepatocyte proliferation in vitro via NF-κB and ERK pathway by targeting bcl2, myc and ccnd1.
these results suggest that RSV possibly, by activating SIRT1 and regulating cMYC transcriptional activity, participates in the regulation of immature Sertoli cell proliferation.
Title: Effect of resveratrol on Sertoli cell proliferation.
High c-myc expression is associated with liver fibrosis.
Title: Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: Role of TGF-β1, IL-10 and c-Myc.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myc (e-PCR), detects polymorphism
- UniSTS:257027

PMC156147P1 (e-PCR)
- UniSTS:271368

G15987 (e-PCR)
- UniSTS:68875

RH129446 (e-PCR)
- UniSTS:212753

D15Mit17 (e-PCR), detects polymorphism
- UniSTS:127542

MYC (e-PCR), detects polymorphism
- UniSTS:504377

Myc (e-PCR), detects polymorphism
- UniSTS:527431

PMC187450P1 (e-PCR)
- UniSTS:271727

MYC (e-PCR), detects polymorphism
- UniSTS:266881

RH94720 (e-PCR)
- UniSTS:119967

PMC148819P4 (e-PCR)
- UniSTS:271017

Myc (e-PCR), detects polymorphism
- UniSTS:256954

d7mit27 (e-PCR)
- UniSTS:120507

PMC165967P4 (e-PCR)
- UniSTS:271552

PMC165967P5 (e-PCR)
- UniSTS:271553

PMC165967P6 (e-PCR)
- UniSTS:271554

D7Wox14 (e-PCR)
- UniSTS:119241

D7Wox15 (e-PCR)
- UniSTS:119242

D15Kyo1 (e-PCR), detects polymorphism
- UniSTS:119242

D7Wox29 (e-PCR)
- UniSTS:119243

Myc (e-PCR), detects polymorphism
- UniSTS:119243

PMC150726P9 (e-PCR)
- UniSTS:271081

D7Arb5 (e-PCR)
- UniSTS:239608

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SCF ubiquitin ligase complex binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic initiation factor eIF2 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables transcription regulator activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within B cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in G0 to G1 transition	IEP Inferred from Expression Pattern more info	PubMed
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in NK T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of acinar cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to arsenite(3-)	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to carbohydrate stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cycloheximide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dimethyl sulfoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to endothelin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estrogen stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrostatic pressure	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lectin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to phorbol 13-acetate 12-myristate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prolactin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to putrescine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in in utero embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in inner mitochondrial membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in lactic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of acinar cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric cap mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric cap mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of rRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of rRNA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in re-entry into mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of somatic stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of telomere maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to alkaloid	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to human chorionic gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to radiation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Myc-Max complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription repressor complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myc proto-oncogene protein

Names: Avian myelocytomatosis viral (v-myc) oncogene homolog; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012603.2 → NP_036735.2 myc proto-oncogene protein

See identical proteins and their annotated locations for NP_036735.2

Status: REVIEWED

Source sequence(s)

AY679730

UniProtKB/Swiss-Prot

A0A8L2Q2H7, P09416, Q6B500

UniProtKB/TrEMBL

A0A9H7DMC0

Related

ENSRNOP00000006188.4, ENSRNOT00000006188.7

Conserved Domains (3) summary

cd00083
Location:366 → 425

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:20 → 359

Myc_N; Myc amino-terminal region

pfam02344
Location:422 → 451

Myc-LZ; Myc leucine zipper domain