U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Eda2r ectodysplasin A2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 245527, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Eda2rprovided by MGI
    Official Full Name
    ectodysplasin A2 receptorprovided by MGI
    Primary source
    MGI:MGI:2442860
    See related
    Ensembl:ENSMUSG00000034457 AllianceGenome:MGI:2442860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xedar; TNFRSF27; 9430060M22Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human EDA2R (ectodysplasin A2 receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 1.0), bladder adult (RPKM 0.7) and 11 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Eda2r in Genome Data Viewer
    Location:
    X C3; X 42.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (96375936..96420786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (97333837..97377234, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47588 Neighboring gene G protein-coupled receptor 15-like Neighboring gene STARR-seq mESC enhancer starr_47589 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47590 Neighboring gene STARR-seq mESC enhancer starr_47591 Neighboring gene STARR-seq mESC enhancer starr_47592 Neighboring gene Kruppel-like factor 17 pseudogene Neighboring gene nuclear encoded tRNA lysine 33 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_47593 Neighboring gene mitochondrial ribosomal protein L10 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway. Guan ZH, et al. Exp Anim, 2024 Oct 23. PMID 38797667, Free PMC Article
    2. EDA2R-NIK signaling in cancer cachexia. Agca S, et al. Curr Opin Support Palliat Care, 2024 Sep 1. PMID 38801457
    3. Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency. Newton K, et al. Mol Cell Biol, 2004 Feb. PMID 14749376, Free PMC Article
    4. Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice. Kwack MH, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31607478
    5. EDA2R mediates podocyte injury in high glucose milieu. Lan X, et al. Biochimie, 2020 Jul. PMID 32304771, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-kappaB signaling pathway.
      Title: Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-κB signaling pathway.
    2. EDA2R-NIK signaling in cancer cachexia.
      Title: EDA2R-NIK signaling in cancer cachexia.
    3. Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.
      Title: Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.
    4. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
      Title: EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
    5. EDA2R mediates podocyte injury in high glucose milieu.
      Title: EDA2R mediates podocyte injury in high glucose milieu.
    6. High expression of EDA2R in the late anagen phase of hair growth.
      Title: Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice.
    7. EDA-A2 transgenic mice exhibited multifocal myodegeneration; this phenotype was not observed in the absence of XEDAR
      Title: Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.
    8. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR
      Title: Repertoire of mouse ectodysplasin-A (EDA-A) isoforms.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC124099

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within programmed cell death RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tumor necrosis factor receptor superfamily member 27
    Names
    EDA-A2 receptor
    X linked ectodysplasin receptor
    X-linked ectodysplasin-A2 receptor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161432.2 → NP_001154904.1  tumor necrosis factor receptor superfamily member 27

      See identical proteins and their annotated locations for NP_001154904.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AL732487
      Consensus CDS
      CCDS30293.1
      UniProtKB/Swiss-Prot
      Q8BM50, Q8BX35
      UniProtKB/TrEMBL
      Q3KP88
      Related
      ENSMUSP00000109463.2, ENSMUST00000113832.2
      Conserved Domains (1) summary
      cd15838
      Location:3 → 118
      TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

    2. NM_001161433.2 → NP_001154905.1  tumor necrosis factor receptor superfamily member 27

      See identical proteins and their annotated locations for NP_001154905.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL732487
      Consensus CDS
      CCDS30293.1
      UniProtKB/Swiss-Prot
      Q8BM50, Q8BX35
      UniProtKB/TrEMBL
      Q3KP88
      Related
      ENSMUST00000126283.8
      Conserved Domains (1) summary
      cd15838
      Location:3 → 118
      TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

    3. NM_175540.6 → NP_780749.3  tumor necrosis factor receptor superfamily member 27

      See identical proteins and their annotated locations for NP_780749.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL732487
      Consensus CDS
      CCDS30293.1
      UniProtKB/Swiss-Prot
      Q8BM50, Q8BX35
      UniProtKB/TrEMBL
      Q3KP88
      Related
      ENSMUSP00000041210.4, ENSMUST00000037353.10
      Conserved Domains (1) summary
      cd15838
      Location:3 → 118
      TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      96375936..96420786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX35.1 GenPept UniProtKB/Swiss-Prot:Q8BX35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous