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    Zfp473 zinc finger protein 473 [ Mus musculus (house mouse) ]

    Gene ID: 243963, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp473provided by MGI
    Official Full Name
    zinc finger protein 473provided by MGI
    Primary source
    MGI:MGI:2442697
    See related
    Ensembl:ENSMUSG00000048012 AllianceGenome:MGI:2442697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf473; zfp-100; D030014N22Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and negative regulation of transcription initiation by RNA polymerase II. Predicted to be located in Cajal body. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and pancreas epithelium. Orthologous to human ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 2.1), testis adult (RPKM 0.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp473 in Genome Data Viewer
    Location:
    7 B3; 7 28.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44380904..44398041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44731480..44748617, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 14 Neighboring gene RIKEN cDNA 2310016G11 gene Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene vaccinia related kinase 3 Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene predicted gene, 29791

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 4932441F21

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 473 homolog
    Names
    zinc finger protein 100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289836.1 → NP_001276765.1  zinc finger protein 473 homolog isoform 1

      See identical proteins and their annotated locations for NP_001276765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK030093, AK050747, BE446988, CD539573
      Consensus CDS
      CCDS21213.1
      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001289837.1 → NP_001276766.1  zinc finger protein 473 homolog isoform 1

      See identical proteins and their annotated locations for NP_001276766.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK050747, BE446988, CD539573
      Consensus CDS
      CCDS21213.1
      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Related
      ENSMUSP00000113774.2, ENSMUST00000120074.8
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001289838.1 → NP_001276767.1  zinc finger protein 473 homolog isoform 2

      See identical proteins and their annotated locations for NP_001276767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      AK036453, AK050747, BE446988, CD539573
      Consensus CDS
      CCDS71952.1
      UniProtKB/TrEMBL
      Q4VA40
      Related
      ENSMUSP00000113316.2, ENSMUST00000118162.8
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:484 → 887
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:754 → 774
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001289839.1 → NP_001276768.1  zinc finger protein 473 homolog isoform 2

      See identical proteins and their annotated locations for NP_001276768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (2), which is shorter than isoform 1.
      Source sequence(s)
      AK036453, BC096555, BE446988
      Consensus CDS
      CCDS71952.1
      UniProtKB/TrEMBL
      Q4VA40
      Related
      ENSMUSP00000113789.2, ENSMUST00000120798.8
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:484 → 887
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:754 → 774
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    5. NM_178734.4 → NP_848849.2  zinc finger protein 473 homolog isoform 1

      See identical proteins and their annotated locations for NP_848849.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC150895, AK030093, AK050747, BE446988
      Consensus CDS
      CCDS21213.1
      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Related
      ENSMUSP00000051069.7, ENSMUST00000060270.13
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44380904..44398041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540879.1 → XP_006540942.1  zinc finger protein 473 homolog isoform X1

      See identical proteins and their annotated locations for XP_006540942.1

      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006540882.1 → XP_006540945.1  zinc finger protein 473 homolog isoform X2

      See identical proteins and their annotated locations for XP_006540945.1

      UniProtKB/TrEMBL
      Q4VA40
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:484 → 887
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:754 → 774
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011250862.1 → XP_011249164.1  zinc finger protein 473 homolog isoform X3

      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:484 → 887
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:754 → 774
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036153114.1 → XP_036009007.1  zinc finger protein 473 homolog isoform X2

      UniProtKB/TrEMBL
      Q4VA40
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:484 → 887
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:754 → 774
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:445 → 470
      zf-H2C2_2; Zinc-finger double domain

    5. XM_006540881.4 → XP_006540944.1  zinc finger protein 473 homolog isoform X1

      See identical proteins and their annotated locations for XP_006540944.1

      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain

    6. XM_006540878.1 → XP_006540941.1  zinc finger protein 473 homolog isoform X1

      See identical proteins and their annotated locations for XP_006540941.1

      UniProtKB/Swiss-Prot
      Q8BI67, Q8BI98, Q8BIB7
      Conserved Domains (4) summary
      cd07765
      Location:23 → 63
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:485 → 888
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:755 → 775
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:446 → 471
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BI67.1 GenPept UniProtKB/Swiss-Prot:Q8BI67

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