Gimap8 GTPase, IMAP family member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gimap8provided by MGI
Official Full Name: GTPase, IMAP family member 8provided by MGI
Primary source: MGI:MGI:2685303
See related: Ensembl:ENSMUSG00000064262 AllianceGenome:MGI:2685303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IAN9; Gm457; IMAP8
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein is larger than the other gene family members and includes three AIG1 domains (corresponding to the AIG1 protein from Arabidopsis thaliana) whereas other family members have one AIG1 domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
Expression: Broad expression in spleen adult (RPKM 7.3), thymus adult (RPKM 6.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 23.62 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48624120..48637809)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48647186..48660875)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GIMAP8 exerts an anti-apoptotic effect in the immune system and is involved in responses to infections
Title: Malaria-suppressible expression of the anti-apoptotic triple GTPase mGIMAP8.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTPase IMAP family member 8

Names: immune-associated nucleotide-binding protein 9; immunity-associated protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077410.1 → NP_001070878.1 GTPase IMAP family member 8 isoform 1

See identical proteins and their annotated locations for NP_001070878.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA289616, AB178029, AK134199, BB033818, BE456621

Consensus CDS

CCDS20108.1

UniProtKB/Swiss-Prot

Q3UZ12, Q75N62

Related

ENSMUSP00000145286.2, ENSMUST00000203083.3

Conserved Domains (1) summary

cd01852
Location:49 → 248

AIG1; AvrRpt2-Induced Gene 1 (AIG1)
NM_001286629.1 → NP_001273558.1 GTPase IMAP family member 8 isoform 2

See identical proteins and their annotated locations for NP_001273558.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region resulting in a frameshift and an early stop codon, compared to variant 2. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154013

Consensus CDS

CCDS85043.1

UniProtKB/TrEMBL

A0A0R3P9C7

Related

ENSMUSP00000077350.5, ENSMUST00000078223.6

Conserved Domains (1) summary

cd01852
Location:49 → 248

AIG1; AvrRpt2-Induced Gene 1 (AIG1)
NM_212486.2 → NP_997651.1 GTPase IMAP family member 8 isoform 1

See identical proteins and their annotated locations for NP_997651.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA289616, AB178029, BB033818, BE456621

Consensus CDS

CCDS20108.1

UniProtKB/Swiss-Prot

Q3UZ12, Q75N62

Related

ENSMUSP00000145255.2, ENSMUST00000203509.2

Conserved Domains (1) summary

cd01852
Location:49 → 248

AIG1; AvrRpt2-Induced Gene 1 (AIG1)