Slc1a7 solute carrier family 1 (glutamate transporter), member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc1a7provided by MGI
Official Full Name: solute carrier family 1 (glutamate transporter), member 7provided by MGI
Primary source: MGI:MGI:2444087
See related: Ensembl:ENSMUSG00000008932 AllianceGenome:MGI:2444087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eaat5; A930031E15Rik
Summary: Enables L-glutamate transmembrane transporter activity; extracellularly glutamate-gated chloride channel activity; and glutamate:sodium symporter activity. Involved in L-glutamate transmembrane transport and chloride transmembrane transport. Acts upstream of or within monoatomic anion transmembrane transport. Located in photoreceptor cell terminal bouton and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including cerebellum; mesenchyme of metanephros; and retina nuclear layer. Orthologous to human SLC1A7 (solute carrier family 1 member 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 C7; 4 50.18 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (107825603..107870726)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (107968406..108013529)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
Title: Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina.
Title: Excitatory Amino Acid Transporter EAAT5 Improves Temporal Resolution in the Retina.
Unitary current amplitudes of EAAT5 anion channels turned out to be approximately twice as high as single-channel amplitudes of GLT-1c.
Title: Functional properties of the retinal glutamate transporters GLT-1c and EAAT5.
Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings.
Title: Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings.
These results indicate that EAAT5 acts as a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals.
Title: The glutamate transporter EAAT5 works as a presynaptic receptor in mouse rod bipolar cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly glutamate-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter uptake	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor cell terminal bouton	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: excitatory amino acid transporter 5

Names: solute carrier family 1 member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146255.3 → NP_666367.3 excitatory amino acid transporter 5

Status: VALIDATED

Source sequence(s)

BC030400

Consensus CDS

CCDS18444.3

UniProtKB/Swiss-Prot

A2A8F0, Q8JZR4

UniProtKB/TrEMBL

Z4YKJ7

Related

ENSMUSP00000102324.5, ENSMUST00000106713.5

Conserved Domains (1) summary

pfam00375
Location:19 → 475

SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

107825603..107870726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006503088.2 → XP_006503151.1 excitatory amino acid transporter 5 isoform X1

UniProtKB/TrEMBL

Z4YKJ7

Conserved Domains (1) summary

pfam00375
Location:28 → 433

SDF; Sodium:dicarboxylate symporter family
XM_006503090.2 → XP_006503153.1 excitatory amino acid transporter 5 isoform X2

Conserved Domains (1) summary

pfam00375
Location:75 → 330

SDF; Sodium:dicarboxylate symporter family