St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: St8sia6provided by MGI
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by MGI
Primary source: MGI:MGI:2386797
See related: Ensembl:ENSMUSG00000003418 AllianceGenome:MGI:2386797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siat8f; ST8SiaVI; 1700007J08Rik
Summary: Enables sialyltransferase activity. Involved in ganglioside biosynthetic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Acts upstream of or within several processes, including blastocyst hatching; glycolipid biosynthetic process; and protein O-linked glycosylation. Predicted to be located in membrane. Is expressed in several structures, including early conceptus; genitourinary system; hindgut diverticulum; notochord; and olfactory epithelium. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 5.5), genital fat pad adult (RPKM 4.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 10.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (13659745..13798659, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (13651018..13794734, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice.
Title: Cutting Edge: Enhanced Antitumor Immunity in ST8Sia6 Knockout Mice.
ST8siVI is involved in rhythmic polysialation in the SCN and that ST8siVI expression provides a novel compartmentation of the mammalian circadian center.
Title: Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488504

AI875066 (e-PCR)
- UniSTS:178573

AI314453 (e-PCR)
- UniSTS:158921

RH124672 (e-PCR)
- UniSTS:161494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carbohydrate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glycolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein O-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: alpha-2,8-sialyltransferase 8F

Names: SIAT8-F; ST8Sia VI; alpha-2, 8-sialyltransferase; alpha2,8-sialyltransferase VI; sialyltransferase 8 (alpha-2, 8-sialyltransferase) F; sialyltransferase 8F; sialyltransferase St8Sia VI; sialytransferase St8Sia VI

NP_665837.1

EC 2.4.99.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.