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    Ntmt2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 240879, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ntmt2provided by MGI
    Official Full Name
    N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2685053
    See related
    Ensembl:ENSMUSG00000040113 AllianceGenome:MGI:2685053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm207; NTM1B; Mettl11b
    Summary
    Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Ntmt2 in Genome Data Viewer
    Location:
    1 H2.1; 1 71.0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163529415..163552801, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163702993..163725232, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02854 Neighboring gene predicted gene, 53641 Neighboring gene predicted gene, 57570 Neighboring gene STARR-seq mESC enhancer starr_02855 Neighboring gene STARR-seq mESC enhancer starr_02856 Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-terminal protein N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-terminal protein N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal protein amino acid methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-terminal Xaa-Pro-Lys N-methyltransferase 2
    Names
    X-Pro-Lys N-terminal protein methyltransferase 1B
    alpha N-terminal protein methyltransferase 1B
    methyltransferase like 11B
    methyltransferase-like protein 11B
    NP_001137428.1
    XP_036020749.1
    XP_036020757.1
    XP_036020760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143956.1 → NP_001137428.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2

      See identical proteins and their annotated locations for NP_001137428.1

      Status: PROVISIONAL

      Source sequence(s)
      BC172048
      Consensus CDS
      CCDS48420.1
      UniProtKB/Swiss-Prot
      B2RXM4
      Related
      ENSMUSP00000124211.2, ENSMUST00000159679.8
      Conserved Domains (1) summary
      cl17173
      Location:63 → 277
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      163529415..163552801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164867.1 → XP_036020760.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:17 → 183
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_036164856.1 → XP_036020749.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:47 → 261
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_036164864.1 → XP_036020757.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X2

      Conserved Domains (1) summary
      cl17173
      Location:2 → 212
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXM4.1 GenPept UniProtKB/Swiss-Prot:B2RXM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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